TRANSFAC-Logo

TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T02425 XX ID T02425 XX DT 29.04.1998 (created); ewi. DT 09.06.2006 (updated); oke. CO Copyright (C), QIAGEN. XX FA HNF-4alpha4 XX SY hepatocyte nuclear factor 4alpha4; HNF4alpha4; NR2A1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G001926 HNF4A; HGNC: HNF4A. XX CL C0002; CC (rec); 2.1.3.2.1.4. XX SZ 504 AA; 56.1 kDa (cDNA) (calc.). XX SQ MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDLLPLRLARLRHPLRHHWSISG SQ GVDSSPQGDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRK SQ NHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLP SQ SINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCE SQ LPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILD SQ ELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDS SQ RGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLH SQ PHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLP SQ GAVATIVKPLSAIPQPTITKQEVI XX SC SPTREMBL #Q14540 XX FT 1 89 A/B region [1]. FT 87 158 SM00399; c4gold. FT 87 162 PS51030; NUCLEAR_REC_DBD_2. FT 88 163 PF00105; Zinc finger, C4 type (two domains). FT 90 155 C region (DNA-binding) [1]. FT 145 167 T-box [4]. FT 156 172 D region [1]. FT 156 418 PF00478; IMP dehydrogenase / GMP reductase domai. FT 167 405 AF-2, interactions with the co-activator PGC-1 [2]. FT 167 405 AF-2, interactions with the co-activator PGC-1 [3]. FT 168 174 A-box [4]. FT 173 407 E region (ligand binding) [1]. FT 219 378 SM00430; holi. FT 222 403 PF00104; Ligand-binding domain of nuclear hormon. FT 408 504 F region [1]. XX FF activator [1]; XX MX M00158 V$COUP_01. MX M00762 V$DR1_Q3. MX M00638 V$HNF4ALPHA_Q6. MX M07321 V$HNF4A_Q3. MX M00764 V$HNF4DR1_Q3. MX M00134 V$HNF4_01. MX M00411 V$HNF4_01_B. MX M00967 V$HNF4_Q6. MX M01031 V$HNF4_Q6_01. MX M01032 V$HNF4_Q6_02. MX M01033 V$HNF4_Q6_03. MX M03828 V$HNF4_Q6_04. XX BS R04591. BS R02179. BS R04454. XX DR TRANSPATH: MO000026411. DR EMBL: Z49825; DR UniProtKB: P41235-4; XX RN [1]; RE0006831. RX PUBMED: 8622695. RA Drewes T., Senkel S., Holewa B., Ryffel G. U. RT Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes RL Mol. Cell. Biol. 16:925-931 (1996). RN [2]; RE0015135. RX PUBMED: 8995295. RA Hadzopoulou-Cladaras M., Kistanova E., Evagelopoulou C., Zeng S., Cladaras C., Ladias J. A. RT Functional domains of the nuclear receptor hepatocyte nuclear factor 4 RL J. Biol. Chem. 272:539-550 (1997). RN [3]; RE0018079. RX PUBMED: 11557972. RA Yoon J. C., Puigserver P., Chen G., Donovan J., Wu Z., Rhee J., Adelmant G., Stafford J., Kahn C. R., Granner D. K., Newgard C. B., Spiegelman B. M. RT Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. RL Nature 413:131-138 (2001). RN [4]; RE0015099. RX PUBMED: 8995424. RA Jiang G., Sladek F. M. RT The DNA binding domain of hepatocyte nuclear factor 4 mediates cooperative, specific binding to DNA and heterodimerization with the retinoid X receptor alpha RL J. Biol. Chem. 272:1218-1225 (1997). XX //