AC T02425
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ID T02425
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DT 29.04.1998 (created); ewi.
DT 09.06.2006 (updated); oke.
CO Copyright (C), QIAGEN.
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FA HNF-4alpha4
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SY hepatocyte nuclear factor 4alpha4; HNF4alpha4; NR2A1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G001926 HNF4A; HGNC: HNF4A.
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CL C0002; CC (rec); 2.1.3.2.1.4.
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SZ 504 AA; 56.1 kDa (cDNA) (calc.).
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SQ MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDLLPLRLARLRHPLRHHWSISG
SQ GVDSSPQGDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRK
SQ NHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLP
SQ SINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCE
SQ LPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILD
SQ ELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDS
SQ RGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLH
SQ PHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLP
SQ GAVATIVKPLSAIPQPTITKQEVI
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SC SPTREMBL #Q14540
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FT 1 89 
A/B region [1].
FT 87 158 
SM00399; c4gold.
FT 87 162 
PS51030; NUCLEAR_REC_DBD_2.
FT 88 163 
PF00105; Zinc finger, C4 type (two domains).
FT 90 155 
C region (DNA-binding) [1].
FT 145 167 
T-box [4].
FT 156 172 
D region [1].
FT 156 418 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 167 405 
AF-2, interactions with the co-activator PGC-1 [2].
FT 167 405 
AF-2, interactions with the co-activator PGC-1 [3].
FT 168 174 A-box [4].
FT 173 407 E region (ligand binding) [1].
FT 219 378 SM00430; holi.
FT 222 403 PF00104; Ligand-binding domain of nuclear hormon.
FT 408 504 F region [1].
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FF activator [1];
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MX M00158 V$COUP_01.
MX M00762 V$DR1_Q3.
MX M00638 V$HNF4ALPHA_Q6.
MX M07321 V$HNF4A_Q3.
MX M00764 V$HNF4DR1_Q3.
MX M00134 V$HNF4_01.
MX M00411 V$HNF4_01_B.
MX M00967 V$HNF4_Q6.
MX M01031 V$HNF4_Q6_01.
MX M01032 V$HNF4_Q6_02.
MX M01033 V$HNF4_Q6_03.
MX M03828 V$HNF4_Q6_04.
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BS R04591.
BS R02179.
BS R04454.
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DR TRANSPATH: MO000026411.
DR EMBL: Z49825;
DR UniProtKB: P41235-4;
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RN [1]; RE0006831.
RX PUBMED: 8622695.
RA Drewes T., Senkel S., Holewa B., Ryffel G. U.
RT Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes
RL Mol. Cell. Biol. 16:925-931 (1996).
RN [2]; RE0015135.
RX PUBMED: 8995295.
RA Hadzopoulou-Cladaras M., Kistanova E., Evagelopoulou C., Zeng S., Cladaras C., Ladias J. A.
RT Functional domains of the nuclear receptor hepatocyte nuclear factor 4
RL J. Biol. Chem. 272:539-550 (1997).
RN [3]; RE0018079.
RX PUBMED: 11557972.
RA Yoon J. C., Puigserver P., Chen G., Donovan J., Wu Z., Rhee J., Adelmant G., Stafford J., Kahn C. R., Granner D. K., Newgard C. B., Spiegelman B. M.
RT Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.
RL Nature 413:131-138 (2001).
RN [4]; RE0015099.
RX PUBMED: 8995424.
RA Jiang G., Sladek F. M.
RT The DNA binding domain of hepatocyte nuclear factor 4 mediates cooperative, specific binding to DNA and heterodimerization with the retinoid X receptor alpha
RL J. Biol. Chem. 272:1218-1225 (1997).
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