AC T02439
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ID T02439
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DT 30.04.1998 (created); ewi.
DT 05.01.2009 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA Irx-3
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004550 Irx3.
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HO Ara, Caup, Mirror (Drosophila).
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CL C0006; homeo; 3.1.4.1.3.
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SF homolog to the homeo domain factors encoded by genes within the Drosophila iroquois locus [1];
SF Irx-3 transcripts are found in the ectoderm (E7.5, end of gastrulation), thickening neural ectoderm (E8.0), prospective midbrain, hindbrain, rostral part of closing neural tube (E8.5), nervous system of midbrain, hindbrain, spinal cord, lateral plate mesoderm, ectodermal layer of branchial arches (E9.5) [2];
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CP (embryo:) neural ectoderm [2]; expression is restricted to the midbrain-hindbrain junction, expression in the developing spinal cord [6].
EX cartilaginous otic capsule,,,Theiler Stage 20; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [7] [6].
EX compact core of the interventricular septum,,,Theiler Stage 15; none; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX compact core of the interventricular septum,,,Theiler Stage 17; none; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX compact core of the interventricular septum,,,Theiler Stage 19; none; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX compact myocardial outer layer of ventricle,,,Theiler Stage 15; none; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX compact myocardial outer layer of ventricle,,,Theiler Stage 17; none; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX compact myocardial outer layer of ventricle,,,Theiler Stage 19; none; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX epithelium of respiratory region of nasal cavity,,,Theiler Stage 23; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX forelimb bud,,,Theiler Stage 15; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX forelimb bud,,,Theiler Stage 17; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX future mesencephalon,,,Theiler Stage 15; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX future metencephalon,,,Theiler Stage 15; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX future pons,,,Theiler Stage 20; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [7] [6].
EX hindlimb,,,Theiler Stage 20; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [7] [6].
EX inner nuclear layer of retina,,,Theiler Stage 25; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX interventricular septum,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX interventricular septum,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX interventricular septum,,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX liver,,,Theiler Stage 17; high; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX neural layer of retina,,,Theiler Stage 21; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX neural tube,,,Theiler Stage 20; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [7] [6].
EX olfactory epithelium,,,Theiler Stage 23; none; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX pharyngeal arches,,,Theiler Stage 20; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [7] [6].
EX rhombencephalon,,,Theiler Stage 15; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX spinal cord,,,Theiler Stage 15; high; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX spinal cord,,,Theiler Stage 17; high; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
EX trabeculae carneae,,,Theiler Stage 15; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX trabeculae carneae,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX trabeculae carneae,,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX trabeculae carneae,endocardial cell,,Theiler Stage 15; none; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX trabeculae carneae,endocardial cell,,Theiler Stage 17; none; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX trabeculae carneae,endocardial cell,,Theiler Stage 19; none; RNA-in situ hybridization (not further specified); RNA (undefined); [5].
EX ventricle of heart (right and left),,,Theiler Stage 17; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [6].
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FF may play a role in specifying the trabecular component of the ventricle [5];
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MX M01318 V$IRX3_01.
MX M01485 V$IRX3_02.
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DR TRANSPATH: MO000026423.
DR UniProtKB: P81067;
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RN [1]; RE0006839.
RX PUBMED: 9427752.
RA Gomez-Skarmeta J. L., Glavic A., de la Calle-Mustienes E., Modolell J., Mayor R.
RT Xiro, a Xenopus homolog of the Drosophila Iroquois complex genes, controls development at the neural plate
RL EMBO J. 17:181-190 (1998).
RN [2]; RE0006840.
RX PUBMED: 9427753.
RA Bellefroid E. J., Kobbe A., Gruss P., Pieler T., Gurdon J. B., Papalopulu N.
RT Xiro3 encodes a Xenopus homolog of the Drosophila Iroquois genes and functions in neural specification
RL EMBO J. 17:191-203 (1998).
RN [3]; RE0006842.
RX PUBMED: 9486539.
RA Bosse A., Zuelch A., Becker M. B., Torres M., Gomez-Skarmeta J. L., Modolell J., Gruss P.
RT Identification of the vertebrate Iroquois gene family with overlapping expression during early development of the nervous system
RL Mech. Dev. 69:169-181 (1997).
RN [4]; RE0015689.
RX PUBMED: 10625552.
RA Bruneau B. G., Bao Z. Z., Tanaka M., Schott J. J., Izumo S., Cepko C. L., Seidman J. G., Seidman C. E.
RT Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand
RL Dev. Biol. 217:266-277 (2000).
RN [5]; RE0015698.
RX PUBMED: 10926765.
RA Christoffels V. M., Keijser A. G., Houweling A. C., Clout D. E., Moorman A. F.
RT Patterning the embryonic heart: identification of five mouse Iroquois homeobox genes in the developing heart
RL Dev. Biol. 224:263-274 (2000).
RN [6]; RE0035294.
RX PUBMED: 10704856.
RA Cohen D. R., Cheng C. W., Cheng S. H., Hui C. C.
RT Expression of two novel mouse Iroquois homeobox genes during neurogenesis.
RL Mech. Dev. 91:317-321 (2000).
RN [7]; RE0035292.
RX PUBMED: 11335133.
RA Mummenhoff J., Houweling A. C., Peters T., Christoffels V. M., Ruther U.
RT Expression of Irx6 during mouse morphogenesis.
RL Mech. Dev. 103:193-195 (2001).
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