AC T02443
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ID T02443
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DT 05.05.1998 (created); tme.
DT 02.04.2009 (updated); ach.
CO Copyright (C), QIAGEN.
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FA FKH5
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SY Fkh-5; FKH5; fork head homolog 5; Mf3 (Mesoderm/Mesenchyme forkhead 3).
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006081 Foxb1.
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CL C0023; fork head; 3.3.1.2.1.
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SF gene located on chromosome 9 [3];
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CP (embryonic) (d 7.5 pc) neural ectoderm, mesoderm, (d 8.5 pc) neural tube, mesoderm, (d 9 pc) somites, (later) neuroepithelium, diencephalon, hindbrain, spinal cord [3]; (adult) brain, hypothalamus [4], thymus [2] [2] [3] [4].
CN (adult) heart, lung, liver, spleen, pancreas, kidney, stomach, intestine, gonads, kin, skeletal muscle, fat [2].
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FF controls development of mammary glands and regions of the Central Nervous System that regulate the milk-ejection reflex [6];
FF Important for brain development: essential for access of mammillary body axons to the thalamus [5];
FF The results from K.O. mice lead to the following conclusions: 1) Fkh-5 is involved in the development of diencephalon, midbrain and the proliferation of the presomitic mesoderm, 2) Postnatal growth is influenced and neurological development impaired, 3) Adult Fkh-5 -/- females lack the milk-ejection reflex [4];
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DR TRANSPATH: MO000026427.
DR UniProtKB: Q64732;
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RN [1]; RE0006655.
RA TRANSFAC_Team.
RT Revisions of transcription factor domains
RL TRANSFAC Reports 1:0002 (1998).
RN [2]; RE0006823.
RX PUBMED: 7689224.
RA Kaestner K. H., Lee K. H., Schloendorff J., Hiemisch H., Monaghan A. P., Schuetz G.
RT Six members of the mouse forkhead gene family are developmentally regulated
RL Proc. Natl. Acad. Sci. USA 90:7628-7631 (1993).
RN [3]; RE0006844.
RX PUBMED: 8861101.
RA Kaestner K. H., Schuetz G., Monaghan A. P.
RT Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system
RL Mech. Dev. 55:221-230 (1996).
RN [4]; RE0006923.
RX PUBMED: 9118797.
RA Labosky P. A., Winnier G. E., Jetton T. L., Hargett L., Ryan A. K., Rosenfeld M. G., Parlow A. F., Hogan B. L. M.
RT The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection refelx
RL Development 124:1263-1274 (1997).
RN [5]; RE0047966.
RX PUBMED: 10662642.
RA Alvarez-Bolado G., Zhou X., Voss A. K., Thomas T., Gruss P.
RT Winged helix transcription factor Foxb1 is essential for access of mammillothalamic axons to the thalamus.
RL Development 127:1029-1038 (2000).
RN [6]; RE0047976.
RX PUBMED: 11170346.
RA Kloetzli J. M., Fontaine-Glover I. A., Brown E. R., Kuo M., Labosky P. A.
RT The winged helix gene, Foxb1, controls development of mammary glands and regions of the CNS that regulate the milk-ejection reflex.
RL Genesis 29:60-71 (2001).
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