AC T02461
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ID T02461
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DT 27.05.1998 (created); tme.
DT 28.10.2014 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA FKHL5
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SY Freac-1 (Forkhead RElated ACtivator-1); HFH-8; HNF-3/Fkh Homolog 8.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G013777 Foxf1.
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CL C0023; fork head; 3.3.1.6.1.
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CP (embryonic) extraembryonic and lateral mesoderm, splanchnic mesoderm [4]; (adult) weak in prostate and placenta, moderate in colon and small intestine [4], type II pneumocytes [3] and fibroblasts [4] of alveolar sac [3] [4].
CN (adult) spleen, thymus, testis, ovary, leukocytes, heart, brain, liver, skeletal muscle, kidney, pancreas.
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FF control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production. [5];
FF is required for differentiation of extra-embryonic and lateral plate mesoderm [7];
FF is essential for normal lung repair and endothelial cell survival in response to pulmonary cell injury [6];
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MX M03573 V$FKHL5_Q3.
MX M00809 V$FOX_Q2.
MX M00294 V$HFH8_01.
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BS R05070.
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DR TRANSPATH: MO000045445.
DR UniProtKB: Q61080;
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RN [1]; RE0006655.
RA TRANSFAC_Team.
RT Revisions of transcription factor domains
RL TRANSFAC Reports 1:0002 (1998).
RN [2]; RE0006874.
RX PUBMED: 7958446.
RA Clevidence D. E., Overdier D. G., Peterson R. S., Porcella A., Ye H., Paulson K. E., Costa R. H.
RT Members of the HNF-3/forkhead family of transcription factors exhibit distinct cellular expression patterns in lung and regulate the surfactant protein B promoter
RL Dev. Biol. 116:195-209 (1994).
RN [3]; RE0006877.
RX PUBMED: 8626802.
RA Hellqvist M., Mahlapuu M., Samuelsson L., Enerbaeck S., Carlsson P.
RT Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2
RL J. Biol. Chem. 271:4482-4490 (1996).
RN [4]; RE0006911.
RX PUBMED: 9486531.
RA Peterson R. S., Linn L., Ye H., Zhou H., Overdier D. G., Costa R. H.
RT The winged helix transcriptional activator HFH-8 is expressed in the mesoderm of the primitive streak stage of mouse embryos and its cellular derivatives
RL Mech. Dev. 69:53-69 (1997).
RN [5]; RE0048271.
RX PUBMED: 16439479.
RA Ormestad M., Astorga J., Landgren H., Wang T., Johansson B. R., Miura N., Carlsson P.
RT Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production.
RL Development 133:833-843 (2006).
RN [6]; RE0048282.
RX PUBMED: 12003781.
RA Kalinichenko V. V., Zhou Y., Shin B., Stolz D. B., Watkins S. C., Whitsett J. A., Costa R. H.
RT Wild-type levels of the mouse Forkhead Box f1 gene are essential for lung repair.
RL Am. J. Physiol. Lung Cell. Mol. Physiol. 282:L1253-65 (2002).
RN [7]; RE0048284.
RX PUBMED: 11124112.
RA Mahlapuu M., Ormestad M., Enerback S., Carlsson P.
RT The forkhead transcription factor Foxf1 is required for differentiation of extra-embryonic and lateral plate mesoderm.
RL Development 128:155-166 (2001).
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