AC T02464
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ID T02464
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DT 05.06.1998 (created); tme.
DT 14.04.2009 (updated); grs.
CO Copyright (C), QIAGEN.
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FA FKHL5
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SY FKHL5; Forkhead RElated ACtivator-1; FREAC1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006092 FOXF1; HGNC: FOXF1.
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CL C0023; fork head; 3.3.1.6.1.
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SF the gene is located on chromosome 16q24 [4];
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CP (fetal) lung; (adult) placenta, lung.
CN (fetal) heart, brain, liver, kidney; (adult) heart, brain, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon, blood leucocytes.
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FF inducesGrowth Hormone Variant gene expression by interaction with FoxF1/FoxF2 cis-element in proximal promoter [6];
FF activates the promoter of the lung specific CC10 gene in the lung cell line (H441) [2];
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MX M03573 V$FKHL5_Q3.
MX M00809 V$FOX_Q2.
MX M00294 V$HFH8_01.
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BS R27149.
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DR TRANSPATH: MO000026445.
DR UniProtKB: Q12946;
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RN [1]; RE0006655.
RA TRANSFAC_Team.
RT Revisions of transcription factor domains
RL TRANSFAC Reports 1:0002 (1998).
RN [2]; RE0006877.
RX PUBMED: 8626802.
RA Hellqvist M., Mahlapuu M., Samuelsson L., Enerbaeck S., Carlsson P.
RT Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2
RL J. Biol. Chem. 271:4482-4490 (1996).
RN [3]; RE0006883.
RX PUBMED: 7957066.
RA Pierrou S., Hellqvist M., Samuelsson L., Enerbaeck S., Carlsson P.
RT Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending
RL EMBO J. 13:5002-5012 (1994).
RN [4]; RE0006884.
RX PUBMED: 8825632.
RA Larsson C., Hellqvist M., Pierrou S., White I., Enerbaeck S., Carlsson P.
RT Chromosomal localization of six human forkhead genes, freac-1(FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12)
RL Genomics 30:464-469 (1995).
RN [5]; RE0047915.
RX PUBMED: 11179011.
RA Saleem R. A., Banerjee-Basu S., Berry F. B., Baxevanis A. D., Walter M. A.
RT Analyses of the effects that disease-causing missense mutations have on the structure and function of the winged-helix protein FOXC1.
RL Am. J. Hum. Genet. 68:627-641 (2001).
RN [6]; RE0048270.
RX PUBMED: 16772323.
RA Lomenick J., Hubert M., Handwerger S.
RT Transcription Factor FOXF1 Regulates Growth Hormone Variant Gene Expression.
RL Am. J. Physiol. Endocrinol. Metab. 291:E947-51 (2006).
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