AC T02472
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ID T02472
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DT 10.06.1998 (created); tme.
DT 16.02.2012 (updated); lat.
CO Copyright (C), QIAGEN.
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FA FREAC4
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SY FKHL8; Forkhead RElated ACtivator-4; FREAC4.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G001224 FOXD1; HGNC: FOXD1.
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CL C0023; fork head; 3.3.1.4.1.
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SF gene is located on chromosome 5q12-q13 [3];
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CP (fetal) kidney (highest expression); (adult) kidney, testis, cells of the monocyte lineage [2].
CN (fetal) heart, brain, lung, liver; (adult) heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen, thymus, prostate, ovary, small intestine, colon, blood leukocytes.
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FF binding of Freac-4/GST fusion protein to recognition sites induced bending of the DNA at an angle of 80-90 degrees [2];
FF WT-1 T00899 and p53 are potential regulators of Freac-4 expression [4];
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MX M00292 V$FREAC4_01.
MX M05356 V$FREAC4_02.
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BS R05068.
BS R73600.
BS R73601.
BS R37933.
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DR TRANSPATH: MO000026453.
DR UniProtKB: Q16676;
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RN [1]; RE0006655.
RA TRANSFAC_Team.
RT Revisions of transcription factor domains
RL TRANSFAC Reports 1:0002 (1998).
RN [2]; RE0006883.
RX PUBMED: 7957066.
RA Pierrou S., Hellqvist M., Samuelsson L., Enerbaeck S., Carlsson P.
RT Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending
RL EMBO J. 13:5002-5012 (1994).
RN [3]; RE0006884.
RX PUBMED: 8825632.
RA Larsson C., Hellqvist M., Pierrou S., White I., Enerbaeck S., Carlsson P.
RT Chromosomal localization of six human forkhead genes, freac-1(FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12)
RL Genomics 30:464-469 (1995).
RN [4]; RE0006885.
RX PUBMED: 8702877.
RA Ernstsson S., Pierrou S., Hulander M., Cederberg A., Hellqvist M., Carlsson P., Enerbaeck S.
RT Characterization of the human forkhead gene FREAC-4. Evidence for regulation by Wilms' tumor supressor gene (WT-1) and p53
RL J. Biol. Chem. 271:21094-21099 (1996).
RN [5]; RE0047915.
RX PUBMED: 11179011.
RA Saleem R. A., Banerjee-Basu S., Berry F. B., Baxevanis A. D., Walter M. A.
RT Analyses of the effects that disease-causing missense mutations have on the structure and function of the winged-helix protein FOXC1.
RL Am. J. Hum. Genet. 68:627-641 (2001).
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