AC T02666
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ID T02666
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DT 23.02.1999 (created); ewi.
DT 11.06.2015 (updated); smt.
CO Copyright (C), QIAGEN.
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FA Pitx3
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SY Pituitary homeobox 3.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005730 Pitx3.
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CL C0006; homeo; 3.1.3.19.3.
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SF 99% amino acid identity to human PITX3 T04311 [2];
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EX Meckel's cartilage,,,Theiler Stage 22; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX Meckel's cartilage,,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX anterior chamber of eyeball,,,Theiler Stage 22; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX anterior chamber of eyeball,,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX anterior chamber of eyeball,,,Theiler Stage 24; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX costal cartilage,,,Theiler Stage 22; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX costal cartilage,,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX cranial skeletal muscle,,,Theiler Stage 20; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX cranial skeletal muscle,,,Theiler Stage 22; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX cranial skeletal muscle,,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX equatorial epithelium of lens,,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX equatorial epithelium of lens,,,Theiler Stage 20; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX equatorial epithelium of lens,,,Theiler Stage 21; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX equatorial epithelium of lens,,,Theiler Stage 22; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX equatorial epithelium of lens,,,Theiler Stage 22; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX equatorial epithelium of lens,,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX equatorial epithelium of lens,,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX equatorial epithelium of lens,,,Theiler Stage 24; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX extra-ocular muscles,,,Theiler Stage 19; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX extra-ocular muscles,,,Theiler Stage 20; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX extra-ocular muscles,,,Theiler Stage 21; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX extra-ocular muscles,,,Theiler Stage 22; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX extra-ocular muscles,,,Theiler Stage 22; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX extra-ocular muscles,,,Theiler Stage 22; medium; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX extra-ocular muscles,,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX extra-ocular muscles,,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX extra-ocular muscles,,,Theiler Stage 24; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX eyelids,,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX femoral pre-cartilage condensation,,,Theiler Stage 22; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX femoral pre-cartilage condensation,,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX future pigment layer,,,Theiler Stage 18; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX future tongue,,,Theiler Stage 20; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX gut,,,Theiler Stage 22; medium; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX incisor primordia,,,Theiler Stage 20; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX incisor primordia,,,Theiler Stage 22; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX incisor primordia,,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX lateral ventricles (right and left),,,Theiler Stage 22; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX lateral ventricles (right and left),,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX lens epithelium,,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX lens fibers,,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX lens pit,,,Theiler Stage 16; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX lens pit,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX lens pit,,,Theiler Stage 17; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX lens placode,,,Theiler Stage 16; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX lens placode,,,Theiler Stage 16; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX lens placode,,,Theiler Stage 16; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX lens vesicle,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX lens vesicle,,,Theiler Stage 18; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX lens vesicle,,,Theiler Stage 18; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX lens vesicle,,,Theiler Stage 18; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX lens vesicle,,,Theiler Stage 19; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX lens,,,Theiler Stage 22; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX lens,,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX lens,,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX lips,,,Theiler Stage 22; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX lips,,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX liver,,,Theiler Stage 22; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX liver,,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX mesencephalon,,,Theiler Stage 20; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX mesencephalon,,,Theiler Stage 22; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX mesencephalon,,,Theiler Stage 22; medium; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX mesencephalon,,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX neural ectoderm of optic vesicle,,,Theiler Stage 13; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX neural ectoderm of optic vesicle,,,Theiler Stage 14; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX neural retinal epithelium,,,Theiler Stage 18; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX optic vesicle,,,Theiler Stage 16; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX optic vesicle,,,Theiler Stage 17; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX pituitary gland of diencephalon,,,Theiler Stage 22; medium; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX pre-cartilage condensation of hyoid bone,,,Theiler Stage 22; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX pre-cartilage condensation of hyoid bone,,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX retinal pigment epithelium,,,Theiler Stage 22; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX skeletal muscle of eye,,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX sternebral bone pre-cartilage condensation,,,Theiler Stage 20; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX tongue,,,Theiler Stage 22; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX tongue,,,Theiler Stage 22; medium; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX tongue,,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
EX vertebra,,,Theiler Stage 20; high; RNA-in situ hybridization (not further specified); RNA (undefined); [2].
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FF role in anterior-chamber and lens development [2];
FF aphakia (ak) mutation (severe ocular abnormalities, small eyes lacking a lens) is caused by a deletion in the promoter region of Pitx3 [1] [3];
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MX M01343 V$PITX3_01.
MX M01735 V$PITX3_Q2.
MX M07057 V$PITX3_Q3.
MX M07392 V$PITX3_Q3_01.
MX M08895 V$PITX_Q4.
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DR TRANSPATH: MO000026642.
DR UniProtKB: O35160;
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RN [1]; RE0013337.
RX PUBMED: 9328475.
RA Semina E. V., Reiter R. S., Murray J. C.
RT Isolation of a new homeobox gene belonging to the Pitx/Rieg family: expression during lens development and mapping to the aphakia region on mouse chromosome 19
RL Hum. Mol. Genet. 6:2109-2116 (1997).
RN [2]; RE0015739.
RX PUBMED: 9620774.
RA Semina E. V., Ferrell R. E., Mintz-Hittner H. A., Bitoun P., Alward W. L., Reiter R. S., Funkhauser C., Daack-Hirsch S., Murray J. C.
RT A novel homeobox gene PITX3 is mutated in families with autosomal-dominant cataracts and ASMD
RL Nat. Genet. 19:167-170 (1998).
RN [3]; RE0015743.
RX PUBMED: 10861284.
RA Semina E. V., Murray J. C., Reiter R., Hrstka R. F., Graw J.
RT Deletion in the promoter region and altered expression of Pitx3 homeobox gene in aphakia mice
RL Hum. Mol. Genet. 9:1575-1585 (2000).
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