AC T02687
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ID T02687
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DT 16.04.1999 (created); vma.
DT 24.06.2015 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA GATA-4
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SY GATA-box binding factor 4.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004007 GATA4; HGNC: GATA4.
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CL C0004; CC; 2.2.1.1.4.
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CP (Caco-2 0239 [1]; First trimester chorionic villi, first and second trimester cytrophoblast cells [4].
CN (HT-29 0792, SW1417 0974 [1].
EX brain,,,adult; none; Northern blot; total RNA; [2].
EX brain,,,adult; none; Northern blot; total RNA; [5].
EX brain,,,fetal; none; Northern blot; total RNA; [5].
EX colon,,,adult; none; Northern blot; total RNA; [5].
EX heart,,,adult; high; Northern blot; total RNA; [2].
EX heart,,,adult; high; Northern blot; total RNA; [5].
EX heart,,,fetal; high; Northern blot; total RNA; [5].
EX heart,,,fetal; low; Northern blot; total RNA; [2].
EX human, Homo sapiens,leucocyte,,adult; none; Northern blot; total RNA; [5].
EX kidney (right and left),,,adult; none; Northern blot; total RNA; [5].
EX kidney (right and left),,,fetal; none; Northern blot; total RNA; [5].
EX liver,,,adult; medium; Northern blot; total RNA; [5].
EX liver,,,adult; none; Northern blot; total RNA; [2].
EX liver,,,fetal; low; Northern blot; total RNA; [5].
EX lung (right and left),,,adult; none; Northern blot; total RNA; [5].
EX lung (right and left),,,fetal; none; Northern blot; total RNA; [5].
EX muscles,,,adult; none; Northern blot; total RNA; [5].
EX ovary (right and left),,,adult; high; Northern blot; total RNA; [5].
EX pancreas,,,adult; high; Northern blot; total RNA; [5].
EX placenta,,,adult; none; Northern blot; total RNA; [5].
EX prostate gland,,,adult; none; Northern blot; total RNA; [5].
EX small intestine,,,adult; none; Northern blot; total RNA; [5].
EX spleen,,,adult; none; Northern blot; total RNA; [5].
EX testis (right and left),,,adult; high; Northern blot; total RNA; [5].
EX thymus,,,adult; none; Northern blot; total RNA; [5].
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FF Nkx2-5 T04323 and Gata-4 synergistically transactivate the rat ANP promoter, whereas Gata-4 alone shows no significant increase in the rat ANP promoter activity [3];
FF Nkx2-5 binding sites, but not Gata sites, are required for Nkx2-5-Gata-4 positive cooperation [3];
FF Nkx2.5 and Gata-4 exhibit negative cooperation on Gata-4 dependent promoters such as human IL-5 gene or the artificial promoter containing multimerized Gata sites and these two factors exhibit positive cooperation on Nkx-2.5 dependent promoters [3];
FF Nkx2.5 reduces the DNA-binding affinity of Gata4 [3];
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IN T04323 CSX; human, Homo sapiens.
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MX M03998 V$GATA4_02.
MX M00632 V$GATA4_Q3.
MX M03549 V$GATA4_Q5_01.
MX M00789 V$GATA_Q6.
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BS R19518.
BS R19520.
BS R19597.
BS R26638.
BS R26636.
BS R20670.
BS R37324.
BS R32237.
BS R28665.
BS R19709.
BS R21089.
BS R20913.
BS R21182.
BS R41605.
BS R41619.
BS R21263.
BS R14541.
BS R37861.
BS R26542.
BS R26543.
BS R37864.
BS R14557.
BS R13027.
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DR TRANSPATH: MO000026663.
DR TRANSCOMPEL: C00191.
DR TRANSCOMPEL: C00521.
DR TRANSCOMPEL: C00522.
DR UniProtKB: P43694;
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RN [1]; RE0013539.
RX PUBMED: 9566909.
RA Gao X., Sedgwick T., Shi Y.-B., Evans T.
RT Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation.
RL Mol. Cell. Biol. 18:2901-2911 (1998).
RN [2]; RE0013561.
RX PUBMED: 7721094.
RA Huang W. Y., Cukerman E., Liew C. C.
RT Identification of a GATA motif in the cardiac alpha-myosin heavy-chain-encoding gene and isolation of a human GATA-4 cDNA.
RL Gene 155:219-223 (1995).
RN [3]; RE0025189.
RX PUBMED: 10075728.
RA Shiojima I., Komuro I., Oka T., Hiroi Y., Mizuno T., Takimoto E., Monzen K., Aikawa R., Akazawa H., Yamazaki T., Kudoh S., Yazaki Y.
RT Context-dependent transcriptional cooperation mediated by cardiac transcription factors Csx/Nkx-2.5 and GATA-4.
RL J. Biol. Chem. 274:8231-8239 (1999).
RN [4]; RE0050011.
RX PUBMED: 15131259.
RA Peng L., Huang Y., Jin F., Jiang S. W., Payne A. H.
RT Transcription enhancer factor-5 and a GATA-like protein determine placental-specific expression of the Type I human 3beta-hydroxysteroid dehydrogenase gene, HSD3B1.
RL Mol. Endocrinol. 18:2049-2060 (2004).
RN [5]; RE0013565.
RX PUBMED: 8975704.
RA Suzuki E., Evans T., Lowry J., Truong L., Bell D. W., Testa J. R., Walsh K.
RT The human GATA-6 gene: structure, chromosomal location, and regulation of expression by tissue-specific and mitogen-responsive signals.
RL Genomics 38:283-290 (1996).
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