AC T02689
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ID T02689
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DT 16.04.1999 (created); vma.
DT 01.02.2013 (updated); sup.
CO Copyright (C), QIAGEN.
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FA GATA-6
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SY GATA binding protein 6; GATA6.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002610 GATA6; HGNC: GATA6.
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CL C0004; CC; 2.2.1.1.6.
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SF order of binding affinity to core is GATA>GATT>GATC [4];
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CP (Caco-2 0239, HT-29 0792 [1].
CN (SW1417 0974 [1].
EX brain,,,adult; none; Northern blot; total RNA; [2].
EX brain,,,fetal; none; Northern blot; total RNA; [2].
EX colon,,,adult; none; Northern blot; total RNA; [2].
EX heart,,,adult; high; RT-PCR; mRNA (poly-A); [2].
EX heart,,,fetal; very high; Northern blot; total RNA; [2].
EX human, Homo sapiens,leucocyte,,adult; none; Northern blot; total RNA; [2].
EX kidney (right and left),,,adult; very low; Northern blot; total RNA; [2].
EX kidney (right and left),,,fetal; none; Northern blot; total RNA; [2].
EX liver,,,adult; medium; Northern blot; total RNA; [2].
EX liver,,,fetal; none; Northern blot; total RNA; [2].
EX lung (right and left),,,adult; high; RT-PCR; mRNA (poly-A); [2].
EX lung (right and left),,,fetal; high; Northern blot; total RNA; [2].
EX muscles,,,adult; none; Northern blot; total RNA; [2].
EX ovary (right and left),,,adult; high; RT-PCR; mRNA (poly-A); [2].
EX pancreas,,,adult; high; RT-PCR; mRNA (poly-A); [2].
EX placenta,,,adult; none; Northern blot; total RNA; [2].
EX prostate gland,,,adult; none; Northern blot; total RNA; [2].
EX small intestine,,,adult; very low; Northern blot; total RNA; [2].
EX spleen,,,adult; medium; Northern blot; total RNA; [2].
EX testis (right and left),,,adult; none; Northern blot; total RNA; [2].
EX thymus,,,adult; none; Northern blot; total RNA; [2].
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FF expressed in undifferentiated and proliferating HT-29 cells 0792, down-regulated after induction with sodium butyrate [1];
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MX M00462 V$GATA6_01.
MX M03216 V$GATA6_Q5.
MX M00789 V$GATA_Q6.
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BS R23675.
BS R30324.
BS R28640.
BS R21667.
BS R37324.
BS R32237.
BS R31921.
BS R36310.
BS R36312.
BS R20913.
BS R41619.
BS R13046.
BS R28728.
BS R26543.
BS R23663.
BS R23667.
BS R23668.
BS R23669.
BS R33544.
BS R28521.
BS R29129.
BS R16086.
BS R32203.
BS R14557.
BS R29902.
BS R32087.
BS R32088.
BS R29127.
BS R31833.
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DR TRANSPATH: MO000026665.
DR UniProtKB: Q92908;
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RN [1]; RE0013539.
RX PUBMED: 9566909.
RA Gao X., Sedgwick T., Shi Y.-B., Evans T.
RT Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation.
RL Mol. Cell. Biol. 18:2901-2911 (1998).
RN [2]; RE0013565.
RX PUBMED: 8975704.
RA Suzuki E., Evans T., Lowry J., Truong L., Bell D. W., Testa J. R., Walsh K.
RT The human GATA-6 gene: structure, chromosomal location, and regulation of expression by tissue-specific and mitogen-responsive signals.
RL Genomics 38:283-290 (1996).
RN [3]; RE0013566.
RX PUBMED: 9315713.
RA Yoshida T., Sato R., Mahmood S., Kawasaki S., Futai M., Maeda M.
RT GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells.
RL FEBS Lett. 414:333-337 (1997).
RN [4]; RE0016786.
RX PUBMED: 9784406.
RA Sakai Y., Nakagawa R., Sato R., Maeda M.
RT Selection of DNA binding sites for human transcriptional regulator GATA-6.
RL Biochem. Biophys. Res. Commun. 250:682-688 (1998).
RN [5]; RE0064744.
RX PUBMED: 18096723.
RA Freund C., Ward-van Oostwaard D., Monshouwer-Kloots J., van den Brink S., van Rooijen M., Xu X., Zweigerdt R., Mummery C., Passier R.
RT Insulin redirects differentiation from cardiogenic mesoderm and endoderm to neuroectoderm in differentiating human embryonic stem cells.
RL Stem Cells 26:724-733 (2008).
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