AC T02733
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ID T02733
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DT 31.05.1999 (created); vma.
DT 22.11.2010 (updated); din.
CO Copyright (C), QIAGEN.
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FA DSIF
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SY DRB sensitivity-inducing factor.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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HO Spt5 + Spt4 (Saccharomyces cerevisiae) [1].
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SF composed of p160 T02734 and p14 T02735 subunits [1];
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FF causes pausing of RNA polymerase II in presence of transcription inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) or H8 [1];
FF DSIF is not sufficient for repression of elongation, NELF T02737 is needed as well [2];
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DR TRANSPATH: MO000026709.
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RN [1]; RE0013618.
RX PUBMED: 9450929.
RA Wada T., Takagi T., Yamaguchi Y., Ferdous A., Imai T., Hirose S., Sugimoto S., Yano K., Hartzog G. A., Winston F., Buratowski S., Handa H.
RT DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs.
RL Genes Dev. 12:343-356 (1998).
RN [2]; RE0013620.
RX PUBMED: 10199401.
RA Yamaguchi Y., Takagi T., Wada T., Yano K., Furuya A., Sugimoto S., Hasegawa J., Handa H.
RT NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation.
RL Cell 97:41-51 (1999).
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