AC T02769
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ID T02769
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DT 08.06.1999 (created); mpr.
DT 31.10.2014 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA SF-1
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SY Ad4BP; fushi tarazu factor homolog 1; NR5A1; steroidogenic factor 1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004015 NR5A1; HGNC: NR5A1.
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HO Ftz-F1.
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CL C0002; CC (rec); 2.1.5.0.1.
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SF pI = 7.49;
SF seems to be an essential transcriptional factor for steroidogenesis as well as for the development of the reproductive axis [2];
SF SF-1 and the thereby regulated genes are necessary for male sexual differentiation [4];
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CP pituitary gonadotrope cells [5].
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FF belongs to small group of orphan nuclear receptors which bind to DNA as monomers and recognizes additional nucleotides upstream of the hexameric half-site (most often AGGTCA motif) [3];
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MX M03802 V$SF1_Q5.
MX M07267 V$SF1_Q5_01.
MX M00727 V$SF1_Q6.
MX M01132 V$SF1_Q6_01.
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BS R20512.
BS R20628.
BS R20629.
BS R20632.
BS R24216.
BS R28184.
BS R26485.
BS R40272.
BS R23905.
BS R24091.
BS R60829.
BS R63449.
BS R63452.
BS R63455.
BS R63458.
BS R63461.
BS R19636.
BS R28189.
BS R27948.
BS R29663.
BS R28522.
BS R28524.
BS R64628.
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DR TRANSPATH: MO000019620.
DR TRANSCOMPEL: C00219.
DR PATHODB: MT010634.
DR UniProtKB: Q13285; STF1_HUMAN.
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RN [1]; RE0013625.
RX PUBMED: 10219237.
RA Nuclear Receptors Nomenclature Committee.
RT A unified nomenclature system for the nuclear receptor superfamily
RL Cell 97:161-163 (1999).
RN [2]; RE0013658.
RX PUBMED: 8806624.
RA Oba K., Yanase T., Nomura M., Morohashi K., Takayanagi R., Nawata H.
RT Structural characterization of human Ad4bp (SF-1) gene
RL Biochem. Biophys. Res. Commun. 226:261-267 (1996).
RN [3]; RE0015434.
RX PUBMED: 10913126.
RA Ito M., Achermann J. C., Jameson J. L.
RT A naturally occurring steroidogenic factor-1 mutation exhibits differential binding and activation of target genes
RL J. Biol. Chem. 275:31708-31714 (2000).
RN [4]; RE0015435.
RX PUBMED: 10369247.
RA Achermann J. C., Ito M., Ito M., Hindmarsh P. C., Jameson J. L.
RT A mutation in the gene encoding steroidogenic factor-1 causes XY sex reversal and adrenal failure in humans
RL Nat. Genet. 22:125-126 (1999).
RN [5]; RE0015452.
RX PUBMED: 8964846.
RA Asa S. L., Bamberger A. M., Cao B., Wong M., Parker K. L., Ezzat S.
RT The transcription activator steroidogenic factor-1 is preferentially expressed in the human pituitary gonadotroph
RL J. Clin. Endocrinol. Metab. 81:2165-2170 (1996).
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