TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02769 XX ID T02769 XX DT 08.06.1999 (created); mpr. DT 31.10.2014 (updated); jtr. CO Copyright (C), QIAGEN. XX FA SF-1 XX SY Ad4BP; fushi tarazu factor homolog 1; NR5A1; steroidogenic factor 1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004015 NR5A1; HGNC: NR5A1. XX HO Ftz-F1. XX CL C0002; CC (rec); XX SF pI = 7.49; SF seems to be an essential transcriptional factor for steroidogenesis as well as for the development of the reproductive axis [2]; SF SF-1 and the thereby regulated genes are necessary for male sexual differentiation [4]; XX CP pituitary gonadotrope cells [5]. XX FF belongs to small group of orphan nuclear receptors which bind to DNA as monomers and recognizes additional nucleotides upstream of the hexameric half-site (most often AGGTCA motif) [3]; XX MX M03802 V$SF1_Q5. MX M07267 V$SF1_Q5_01. MX M00727 V$SF1_Q6. MX M01132 V$SF1_Q6_01. XX BS R20512. BS R20628. BS R20629. BS R20632. BS R24216. BS R28184. BS R26485. BS R40272. BS R23905. BS R24091. BS R60829. BS R63449. BS R63452. BS R63455. BS R63458. BS R63461. BS R19636. BS R28189. BS R27948. BS R29663. BS R28522. BS R28524. BS R64628. XX DR TRANSPATH: MO000019620. DR TRANSCOMPEL: C00219. DR PATHODB: MT010634. DR UniProtKB: Q13285; STF1_HUMAN. XX RN [1]; RE0013625. RX PUBMED: 10219237. RA Nuclear Receptors Nomenclature Committee. RT A unified nomenclature system for the nuclear receptor superfamily RL Cell 97:161-163 (1999). RN [2]; RE0013658. RX PUBMED: 8806624. RA Oba K., Yanase T., Nomura M., Morohashi K., Takayanagi R., Nawata H. RT Structural characterization of human Ad4bp (SF-1) gene RL Biochem. Biophys. Res. Commun. 226:261-267 (1996). RN [3]; RE0015434. RX PUBMED: 10913126. RA Ito M., Achermann J. C., Jameson J. L. RT A naturally occurring steroidogenic factor-1 mutation exhibits differential binding and activation of target genes RL J. Biol. Chem. 275:31708-31714 (2000). RN [4]; RE0015435. RX PUBMED: 10369247. RA Achermann J. C., Ito M., Ito M., Hindmarsh P. C., Jameson J. L. RT A mutation in the gene encoding steroidogenic factor-1 causes XY sex reversal and adrenal failure in humans RL Nat. Genet. 22:125-126 (1999). RN [5]; RE0015452. RX PUBMED: 8964846. RA Asa S. L., Bamberger A. M., Cao B., Wong M., Parker K. L., Ezzat S. RT The transcription activator steroidogenic factor-1 is preferentially expressed in the human pituitary gonadotroph RL J. Clin. Endocrinol. Metab. 81:2165-2170 (1996). XX //