AC T02785
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ID T02785
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DT 28.07.1999 (created); mpr.
DT 05.04.2010 (updated); jig.
CO Copyright (C), QIAGEN.
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FA Hesx1
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SY Hes1; Rathke's pouch homeobox protein; Rathke's pouch homeobox protein; Rpx.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006198 Hesx1.
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HO Xanf1 (Xenopus).
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CL C0018; paired-homeo; 3.1.3.10.1.
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SF earliest known marker for the pituitary primordium [3];
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CP forebrain tissue (early development), developing pituitary gland [2] [3]; undiff. ES cells, (embryo 7-8.5 days:) prechordal plate precursor, ectoderm of cephalic neural plate, prospective prosencephalon, (embryo 9-14.5 days:) Rathke's pouch [3] [2] [3].
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FF plays an important role in the regulation of developmental decisions in the early mouse embryo and during fetal hematopoiesis [1];
FF involved in the initial determination of the anterior (prechordal) region of the embryo [3];
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DR TRANSPATH: MO000026757.
DR UniProtKB: Q61658;
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RN [1]; RE0011563.
RX PUBMED: 7876132.
RA Thomas P. Q., Johnson B. V., Rathjen J., Rathjen P. D.
RT Sequence, genomic organization, and expression of the novel homeobox gene Hesx1
RL J. Biol. Chem. 270:3869-3875 (1995).
RN [2]; RE0013770.
RX PUBMED: 9620767.
RA Dattani M. T., Martinez-Barbera J.-P., Thomas P. Q., Brickman J. M., Gupta R., Martensson I.-L., Toresson H., Fox M., Wales J. K. H., Hindmarsh P. C., Krauss S., Beddington R. S. P., Robinson I. C. A. F.
RT Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse
RL Nat. Genet. 19:125-133 (1998).
RN [3]; RE0014753.
RX PUBMED: 8565852.
RA Hermesz E., Mackem S., Mahon K. A.
RT Rpx: a novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke's pouch of the mouse embryo
RL Development 122:41-52 (1996).
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