AC T02858
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ID T02858
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DT 12.01.2000 (created); sur.
CO Copyright (C), QIAGEN.
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FA TCF-3B
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SY XTCF-3B.
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OS clawed frog, Xenopus laevis
OC eukaryota; animalia; metazoa; chordata; vertebrata; amphibia; lissamphibia; anura; archeobatrachia; pipoidea; pipidae
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CL C0015; HMG.
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SZ 466 AA; 50.6 kDa (calc.).
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SQ PPKCFRGPPYAGYPFLMIPDLGGHYLPNGALSPSARTYLQMKWPLLDSPSTAGLKDARSP
SQ SPAHLSNKVPVVQHPHHMHPLTPLITYSNEHFSPGTPPGHLSPEIDPKTGIPRPPHPSEL
SQ SPYYPLSPGAVGQIPHPLGWLVPPQGQPMYSIPPGGFRHPYPALAMNASMSSLVSSRFSP
SQ HMVPPPHHSLHTSGIPHPAIVSPIVKQEPSSGNISPNLHTKSNMIVKKEEEKKPHIKKPL
SQ NAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHSLSREEQAKYYELARKERQLHSQLY
SQ PSWSARDNYGKRKKRKREKQSPEMETHTKTKKMCVQHLPADKSCDSPASSHGSMLDSPAT
SQ PSAALASPAAPAATHSEQAQPLSLTTKPEARAQLSLSHSAAFLASKSPSSSRKTGHLSSP
SQ VGSPLLSRPIPLTSSILSPSGVFPSALQALPLLQAQPLSLVTKSSD
XX
SC translated from EMBL #X99308; conflict AA 1-4 not shown in [1]
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FT 235 305 
SM00398; hmgende2.
FT 236 304 
PF00505; HMG (high mobility group) box.
FT 236 304 
PS50118; HMG_BOX_2.
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SF homolog of the mammalian HMG box factors TCF-1 and LEF-1;
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CP maternal.
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FF fragment: N terminal region with respect to XTCF-3, XTCF-3C, XTCF-3D is missing;
FF no complex formation between XTCF-3B and beta-catenin possible;
FF no transcription activation;
FF (dominant negative delta-N mutant);
FF delta-N mutant suppresses the induction of axis duplication by microinjected beta-catenin and suppresses endogenous axis specification upon injection into dorsal blastomeres of a 4-cell-stage embryo [1];
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IN T03243 CtBP; clawed frog, Xenopus laevis.
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MX M01594 V$TCF3_01.
MX M03858 V$TCF3_Q6.
MX M08901 V$TCF3_Q6_01.
MX M08902 V$TCF7RELATED_Q4.
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DR TRANSPATH: MO000026827.
DR EMBL: X99311;
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RN [1]; RE0013000.
RX PUBMED: 8756721.
RA Molenaar M., van de Wetering M., Oosterwegel M., Peterson-Maduro J., Godsave S., Korinek V., Roose J., Destree O., Clevers H.
RT XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos
RL Cell 86:391-399 (1996).
RN [2]; RE0014221.
RX PUBMED: 10375506.
RA Brannon M., Brown J. D., Bates R., Kimelman D., Moon R. T.
RT XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development
RL Development 126:3159-3170 (1999).
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