TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02898 XX ID T02898 XX DT 14.01.2000 (created); rio. DT 25.06.2015 (updated); asv. CO Copyright (C), QIAGEN. XX FA Pax-8 XX SY hPax-8; hPax8; PAX8. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G003972 PAX8; HGNC: PAX8. XX CL C0017; paired; XX SF there are many splice variants (Pax-8a to 8f) four of them (Pax-8a to -8d) being cloned from man [1]; XX CP Thyroid tissue, adenocarcinoma and differentiated carcinoma [3]. XX FF tumor initiation by inhibiting the p53 transcription [2]; XX MX M00717 V$PAX8_01. MX M00328 V$PAX8_B. MX M00808 V$PAX_Q6. XX BS R68569. BS R08517. BS R34175. BS R08566. XX DR TRANSPATH: MO000026866. DR UniProtKB: Q06710; XX RN [1]; RE0004297. RX PUBMED: 8413205. RA Kozmik Z., Kurzbauer R., Doerfler P., Busslinger M. RT Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties RL Mol. Cell. Biol. 13:6024-6035 (1993). RN [2]; RE0011183. RX PUBMED: 8521821. RA Stuart E. T., Haffner R., Oren M., Gruss P. RT Loss of p53 function through PAX-mediated transcriptional repression RL EMBO J. 14:5638-5645 (1995). RN [3]; RE0050155. RX PUBMED: 15062550. RA Puppin C., Presta I., D'Elia A. V., Tell G., Arturi F., Russo D., Filetti S., Damante G. RT Functional interaction among thyroid-specific transcription factors: Pax8 regulates the activity of Hex promoter. RL Mol. Cell. Endocrinol. 214:117-125 (2004). XX //