AC T02898
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ID T02898
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DT 14.01.2000 (created); rio.
DT 25.06.2015 (updated); asv.
CO Copyright (C), QIAGEN.
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FA Pax-8
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SY hPax-8; hPax8; PAX8.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003972 PAX8; HGNC: PAX8.
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CL C0017; paired; 3.2.2.2.3.
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SF there are many splice variants (Pax-8a to 8f) four of them (Pax-8a to -8d) being cloned from man [1];
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CP Thyroid tissue, adenocarcinoma and differentiated carcinoma [3].
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FF tumor initiation by inhibiting the p53 transcription [2];
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MX M00717 V$PAX8_01.
MX M00328 V$PAX8_B.
MX M00808 V$PAX_Q6.
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BS R68569.
BS R08517.
BS R34175.
BS R08566.
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DR TRANSPATH: MO000026866.
DR UniProtKB: Q06710;
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RN [1]; RE0004297.
RX PUBMED: 8413205.
RA Kozmik Z., Kurzbauer R., Doerfler P., Busslinger M.
RT Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties
RL Mol. Cell. Biol. 13:6024-6035 (1993).
RN [2]; RE0011183.
RX PUBMED: 8521821.
RA Stuart E. T., Haffner R., Oren M., Gruss P.
RT Loss of p53 function through PAX-mediated transcriptional repression
RL EMBO J. 14:5638-5645 (1995).
RN [3]; RE0050155.
RX PUBMED: 15062550.
RA Puppin C., Presta I., D'Elia A. V., Tell G., Arturi F., Russo D., Filetti S., Damante G.
RT Functional interaction among thyroid-specific transcription factors: Pax8 regulates the activity of Hex promoter.
RL Mol. Cell. Endocrinol. 214:117-125 (2004).
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