AC T03231
XX
ID T03231
XX
DT 03.04.2000 (created); hom.
DT 21.02.2014 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA Crz1p
XX
SY CRZ1; CRZ1p; HAL8; TCN1; YNL027W.
XX
OS yeast, Saccharomyces cerevisiae
OC Eukaryota; Fungi; Ascomycota; Hemiascomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
XX
GE G004287 CRZ1.
XX
CL C0001; CH.
XX
SZ 678 AA; 76.3 kDa (gene) (calc.), 97 kDa (SDS)
XX
SQ MSFSNGNMASYMTSSNGEEQSINNKNDIDDNSAYRRNNFRNSSNSGSHTFQLSDLDLDVD
SQ MRMDSANSSEKISKNLSSGIPDSFDSNVNSLLSPSSGSYSADLNYQSLYKPDLPQQQLQQ
SQ QQLQQQQQQQQQQQQQQQKQTPTLKVEQSDTFQWDDILTPADNQHRPSLTNQFLSPRSNY
SQ DGTTRSSGIDSNYSDTESNYHTPYLYPQDLVSSPAMSHLTANNDDFDDLLSVASMNSNYL
SQ LPVNSHGYKHISNLDELDDLLSLTYSDNNLLSASNNSDFNNSNNGIINTADTQNSTIAIN
SQ KSKVGTNQKMLLTIPTSSTPSPSTHAAPVTPIISIQEFNEGHFPVKNEDDGTLQLKVRDN
SQ ESYSATNNNNLLRPDDNDYNNEALSDIDRSFEDIINGRKLKLKKSRRRSSQTSNNSFTSR
SQ RSSRSRSISPDEKAKSISANREKLLEMADLLPSSENDNNRERYDNDSKTSYNTINSSNFN
SQ EDNNNNNLLTSKPKIESGIVNIKNELDDTSKDLGILLDIDSLGQFEQKVGFKNDDNHENN
SQ DNGTFSVKKNDNLEKLDSVTNNRKNPANFACDVCGKKFTRPYNLKSHLRTHTNERPFICS
SQ ICGKAFARQHDRKRHEDLHTGKKRYVCGGKLKDGKPWGCGKKFARSDALGRHFKTESGRR
SQ CITPLYEEARQEKSGQES
XX
SC Swiss-Prot#P53968
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FT 46 436 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 569 591 
PF00096; zf-C2H2.
FT 569 591 
SM00355; c2h2final6.
FT 569 596 
PS50157; ZINC_FINGER_C2H2_2.
FT 597 619 
PF00096; zf-C2H2.
FT 597 619 
SM00355; c2h2final6.
FT 597 624 
PS50157; ZINC_FINGER_C2H2_2.
FT 625 661 
PS50157; ZINC_FINGER_C2H2_2.
XX
SF amino acids 186-232 are required for calcineurin-dependent regulation of localization and phosphorylation;
SF this region has sequence similarity to the serine-rich region (SSR) of mammalian NF-AT [2];
SF contains a docking site PIISIQ for calcineurin similar to the PxIxIT calcineurin docking site found in mammalian NFAT transcription factor [3];
XX
FF calcineurin-dependent transcription factor;
FF Crz1p-dependent genes are differentially controlled in response to physiological Ca2+ signals generated by treatment with mating pheromone and high salt [1];
FF Crz1p is activated by calcineurin which promotes nuclear localization through dephosphorylation, promoting import and down-regulating export [3];
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MX M01646 F$CRZ1_01.
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BS R29466.
BS R29467.
BS R12412.
BS R60478.
BS R60480.
XX
DR EMBL: U53876;
DR EMBL: Z49975;
DR EMBL: Z71303;
DR EMBL: Z73270;
DR UniProtKB: P53968;
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RN [1]; RE0014455.
RX PUBMED: 9407036.
RA Matheos D. P., Kingsbury T. J., Ahsan U. S., Cunningham K. W.
RT Tcn1p/Crz1p, a calcineurin-dependent transcription factor that differentially regulates gene expression in Saccharomyces cerevisiae
RL Genes Dev. 11:3445-3458 (1997).
RN [2]; RE0014456.
RX PUBMED: 10197980.
RA Stathopoulos-Gerontides A., Guo J. J., Cyert M. S.
RT Yeast calcineurin regulates nuclear localization of the Crz1p transcription factor through dephosphorylation
RL Genes Dev. 13:798-803 (1999).
RN [3]; RE0017621.
RX PUBMED: 11877380.
RA Boustany L. M., Cyert M. S.
RT Calcineurin-dependent regulation of Crz1p nuclear export requires Msn5p and a conserved calcineurin docking site.
RL Genes Dev. 16:608-619 (2002).
XX
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