AC T03233
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ID T03233
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DT 04.04.2000 (created); rio.
DT 20.11.2007 (updated); sba.
CO Copyright (C), QIAGEN.
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FA HOXC11
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SY CE-LPH1-binding factor; Hox-3.7; HOX3.7; HOX3H.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006221 HOXC11; HGNC: HOXC11.
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HO Abd-B (Drosophila).
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CL C0006; homeo; 3.1.1.8.9.
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SF previously detected and designated as intestinal nuclear factor binding to the lactase-phlorizin hydrolase promoter (NF-LPH1) [1];
SF two HOXC11 transcript sizes (1.7 kb and 2.1 kb) identified by Northern blot analysis [2];
SF downregulated in adolescence and adult stage [2] [1];
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CP (fetus:) small intestine, kidney, skeletal muscle, cell lines (HeLa cells, Caco-2 cells) [2].
CN (fetus:) brain, heart, liver, lung, spleen, thymus, (15 years old:) small intestine [2].
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FF probably involved in the post-weaning decline of lactase-phlorizin hydrolase (LPH) causing lactose intolerance [2] [3] [1];
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MX M07456 V$HOXA913_Q4.
MX M01329 V$HOXC11_01.
MX M04353 V$HOXC11_03.
MX M04354 V$HOXC11_04.
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BS R08848.
BS R36407.
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DR TRANSPATH: MO000027180.
DR TRANSCOMPEL: C00280.
DR UniProtKB: O43248;
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RN [1]; RE0008106.
RX PUBMED: 1400359.
RA Troelsen J. T., Olsen J., Noren O., Sjoestroem H.
RT A novel intestinal trans-factor (NF-LPH1) interacts with the lactase-phlorizin hydrolase promoter and co-varies with the enzymatic acivity
RL J. Biol. Chem. 267:20407-20411 (1992).
RN [2]; RE0014368.
RX PUBMED: 9582375.
RA Mitchelmore C., Troelsen J. T., Sjoestroem H., Noren O.
RT The HOXC11 homeodomain protein interacts with the lactase-phlorizin hydrolase promoter and stimulates HNF1alpha-dependent transcription
RL J. Biol. Chem. 273:13297-13306 (1998).
RN [3]; RE0014372.
RX PUBMED: 8150087.
RA Troelsen J. T., Mehlum A., Olsen J., Spodsberg N., Hansen G. H., Prydz H., Noren O., Sjoestroem H.
RT 1 kb of the lactase-phlorizin hydrolase promoter directs post-weaning decline and small intestinal-specific expression in transgenic mice
RL FEBS Lett. 342:291-296 (1994).
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