AC T03257
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ID T03257
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DT 26.04.2000 (created); rio.
DT 24.02.2012 (updated); grs.
CO Copyright (C), QIAGEN.
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FA HNF-6alpha
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SY HNF-6; HNF-6A.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004831 Onecut1.
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HO Cut (Drosophila).
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CL C0006; homeo.
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SZ 465 AA; 51.1 kDa (cDNA) (calc.), 53-55 kDa (SDS) [1]
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SQ MNAQLTMEAIGELHGVSHEPVPAPADLLGGSPHARSSVGHRGSHLPPAHPRSMGMASLLD
SQ GGSGGSDYHHHHRAPEHSLAGPLHPTMTMACETPPGMSMPTTYTTLTPLQPLPPISTVSD
SQ KFPHHHHHHHHHHHPHHHQRLAGNVSGSFTLMRDERGLASMNNLYTPYHKDVAGMGQSLS
SQ PLSGSGLGSIHNSQQGLPHYAHPGAAMPTDKMLTPNDFEAHHPAMLGRHGEQHLTPTSAG
SQ MVPINGLPPHHPHAHLNAQGHGQLLGTAREPNPSVTGAQVSNGSNSGQMEEINTKEVAQR
SQ ITTELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQ
SQ RMSALRLAACKRKEQEHGKDRGNTPKKPRLVFTDVQRRTLHAIFKENKRPSKELQITISQ
SQ QLGLELSTVSNFFMNARRRSLDKWQDEGSSNSGNSSSSSSTCTKA
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SC Swiss-Prot#P70512-1
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FT 283 369 
PF02376; CUT domain.
FT 283 369 
PS51042; CUT.
FT 383 443 
PS50071; HOMEOBOX_2.
FT 384 444 
PS50560; CUT_HOMEODOMAIN.
FT 385 447 
SM00389; HOX_1.
FT 386 442 
PF00046; Homeobox domain.
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SF Both homeodomain and cut domain of this protein are required for its binding to the sites R20374, and R20376 in the enhancer III of rat AFP gene G000691 [5];
SF ONECUT class of homeodomain proteins [2];
SF the two isoforms differ by the linker that separates cut and homeo domain, the affinity of both isoforms for DNA is different depending on the target sequence, both isoforms are binding as monomers whereas cut and/or homeo domain can be involved in binding [2];
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CP (adult:) liver, brain, testis, spleen [1].
CN (adult:) lung, kidney, adipose tissue, heart, muscle, small intestine, thymus [1].
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FF transcriptional activator [1] [3];
FF involved in regulation of liver and intestinal gene expression [2] [3];
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IN T15118 CBP; Mammalia.
IN T06298 p53; monkey, Cercopithecus aethiops.
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MX M03829 V$HNF6_Q4.
MX M00639 V$HNF6_Q6.
MX M07357 V$HNF6_Q6_01.
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BS R13047.
BS R08921.
BS R08910.
BS R08923.
BS R01464.
BS R08922.
BS R08916.
BS R20374.
BS R20376.
BS R08915.
BS R08924.
BS R08911.
BS R08912.
BS R02988.
BS R08914.
BS R08917.
BS R08894.
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DR TRANSPATH: MO000027195.
DR TRANSCOMPEL: C00543.
DR EMBL: X96553;
DR UniProtKB: P70512-1;
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RN [1]; RE0013188.
RX PUBMED: 8790352.
RA Lemaigre F. P., Durviaux S. M., Truong O., Lannoy V. J., Hsuan J. J., Rousseau G. G.
RT Hepatocyte nuclear factor 6, a transcription factor that contains a novel type of homeodomain and a single cut domain
RL Proc. Natl. Acad. Sci. USA 93:9460-9464 (1996).
RN [2]; RE0014432.
RX PUBMED: 9593691.
RA Lannoy V. J., Burglin T. R., Rousseau G. G., Lemaigre F. P.
RT Isoforms of hepatocyte nuclear factor-6 differ in DNA-binding properties, contain a bifunctional homeodomain, and define the new ONECUT class of homeodomain proteins
RL J. Biol. Chem. 273:13552-13562 (1998).
RN [3]; RE0014471.
RX PUBMED: 8887657.
RA Samadani U., Costa R. H.
RT The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression
RL Mol. Cell. Biol. 16:6273-6284 (1996).
RN [4]; RE0042447.
RX PUBMED: 10811635.
RA Lannoy V. J., Rodolosse A., Pierreux C. E., Rousseau G. G., Lemaigre F. P.
RT Transcriptional stimulation by hepatocyte nuclear factor-6. Target-specific recruitment of either CREB-binding protein (CBP) or p300/CBP-associated factor (p/CAF)
RL J. Biol. Chem. 275:22098-103 (2000).
RN [5]; RE0049044.
RX PUBMED: 12379144.
RA Nacer-Cherif H., Bois-Joyeux B., Rousseau G. G., Lemaigre F. P., Danan J. L.
RT Hepatocyte nuclear factor-6 stimulates transcription of the alpha-fetoprotein gene and synergizes with the retinoic-acid-receptor-related orphan receptor alpha-4.
RL Biochem. J. 369:583-591 (2003).
RN [6]; RE0068251.
RX PUBMED: 16895524.
RA Maeda Y., Hwang-Verslues W. W., Wei G., Fukazawa T., Durbin M. L., Owen L. B., Liu X., Sladek F. M.
RT Tumour suppressor p53 down-regulates the expression of the human hepatocyte nuclear factor 4alpha (HNF4alpha) gene.
RL Biochem. J. 400:303-313 (2006).
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