AC T03261
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ID T03261
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DT 28.04.2000 (created); rio.
DT 17.07.2008 (updated); tgo.
CO Copyright (C), QIAGEN.
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FA Six-2
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SY sine oculis-related homeobox 2 homolog (Drosophila); SIX2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006721 Six2.
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HO sine oculis (Drosophila).
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CL C0006; homeo; 3.1.6.1.2.
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SF Six proteins can be subdivided into three major families on the basis of sequence conservation in their homeo domain and six domain (Six-1/2/11, Six-3/6/7/10, Six-4/5/8) [3];
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CP (8.5-9.5 d:) head mesoderm, foregut, spinal cord, branchial arches, (10.5-11.5 d:) nephrotomes, pharyng.-oesoph. mesenchyme, somites, limbs (tendons), (12.5-16 d:) pyloric region, kidney, stomach, genital tubercle, head bones/muscles [1]; retina [2] [1] [2].
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FF Six-1 and Six-2 are involved in patterning limb connective tissue [1];
FF probably involved in determination and maintenance of the retina [2];
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MX M01433 V$SIX2_01.
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BS R57224.
BS R57225.
BS R73152.
BS R18827.
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DR TRANSPATH: MO000027199.
DR UniProtKB: Q62232;
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RN [1]; RE0014435.
RX PUBMED: 7720577.
RA Oliver G., Wehr R., Jenkins N. A., Copeland N. G., Cheyette B. N., Hartenstein V., Zipursky S. L., Gruss P.
RT Homeobox genes and connective tissue patterning
RL Development 121:693-705 (1995).
RN [2]; RE0014436.
RX PUBMED: 8814301.
RA Kawakami K., Ohto H., Takizawa T., Saito T.
RT Identification and expression of six family genes in mouse retina
RL FEBS Lett. 393:259-263 (1996).
RN [3]; RE0014529.
RX PUBMED: 10381573.
RA Seo H. C., Curtiss J., Mlodzik M., Fjose A.
RT Six class homeobox genes in drosophila belong to three distinct families and are involved in head development
RL Mech. Dev. 83:127-139 (1999).
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