AC T03272
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ID T03272
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DT 02.05.2000 (created); rio.
DT 08.10.2009 (updated); mka.
CO Copyright (C), QIAGEN.
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FA Six-6
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SY Optic homeobox 2; Optx-2; Optx2; Sine oculis homeobox homolog 6; Six-9; Six6.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006725 Six6.
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HO sine oculis (Drosophila), optix (Drosophila).
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CL C0006; homeo; 3.1.6.2.2.
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SF Six-6 is highly related to Six-3 with an amino acid identity of 98% [1];
SF Six-6 and Six-3 are paralogs [3];
SF Six proteins can be subdivided into three major families on the basis of sequence conservation in their homeo domain and six domain (Six-1/2/11, Six-3/6/7/10, Six-4/5/8) [4];
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CP (embryo 8-8.25 days:) somites, prospective forebrain, ventral diencephalon, (embryo 9.5-17.5days:) optic stalk, neural retina, optic chiasm, diencephalon (hypothalamus, neurohypophysis), olfactory placode [1]; E8.25 rostral portion of the neural plate, neural and surface ectoderm; E8.5 ventral forebrain and optical vesicles; E9.5 optic vesicle, optic chiasm and optic nerve; E10.5 anterior rim of the nasal placode and neural retina E13.5 cells of the neural retina near the pigment epithelium; adult mouse retina: cells in the vitreal face of the inner nuclear layer, and in the ganglion cell layer [5].
CN lens placode, retina of newborns, mature photoreceptors of the mouse retina [5].
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FF probably involved in eye development but acts in a pathway independent of Pax-6 [1];
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MX M01345 V$SIX6_01.
MX M01398 V$SIX6_02.
MX M02897 V$SIX6_08.
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DR TRANSPATH: MO000027210.
DR UniProtKB: Q9QZ28;
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RN [1]; RE0014443.
RX PUBMED: 10473118.
RA Jean D., Bernier G., Gruss P.
RT Six6 (Optx2) is a novel murine Six3-related homeobox gene that demarcates the presumptive pituitary/hypothalamic axis and the ventral optic stalk
RL Mech. Dev. 84:31-40 (1999).
RN [2]; RE0014444.
RX PUBMED: 9724757.
RA Toy J., Yang J. M., Leppert G. S., Sundin O. H.
RT The optx2 homeobox gene is expressed in early precursors of the eye and activates retina-specific genes
RL Proc. Natl. Acad. Sci. USA 95:10643-10648 (1998).
RN [3]; RE0014452.
RX PUBMED: 10512683.
RA Gallardo M. E., Lopez-Rios J., Fernaud-Espinosa I., Granadino B., Sanz R., Ramos C., Ayuso C., Seller M. J., Brunner H. G., Bovolenta P., Rodriguez de Cordoba S.
RT Genomic cloning and characterization of the human homeobox gene SIX6 reveals a cluster of SIX genes in chromosome 14 and associates SIX6 hemizygosity with bilateral anophthalmia and pituitary anomalies
RL Genomics 61:82-91 (1999).
RN [4]; RE0014529.
RX PUBMED: 10381573.
RA Seo H. C., Curtiss J., Mlodzik M., Fjose A.
RT Six class homeobox genes in drosophila belong to three distinct families and are involved in head development
RL Mech. Dev. 83:127-139 (1999).
RN [5]; RE0047598.
RX PUBMED: 10381579.
RA Toy J., Sundin O. H.
RT Expression of the optx2 homeobox gene during mouse development.
RL Mech. Dev. 83:183-186 (1999).
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