AC T03279
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ID T03279
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DT 05.05.2000 (created); rio.
DT 20.11.2007 (updated); sba.
CO Copyright (C), QIAGEN.
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FA Six-6
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SY Optx-2; Optx2; Six-9; Six6; Six9.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006724 SIX6; HGNC: Six6.
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HO sine oculis (Drosophila), optix (Drosophila).
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CL C0006; homeo; 3.1.6.2.2.
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SF Six-6 and Six-3 are paralogs [1];
SF Six proteins can be subdivided into three major families on the basis of sequence conservation in their homeo domain and six domain (Six-1/2/11, Six-3/6/7/10, Six-4/5/8) [2];
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CP (embryo 12-14 weeks:) embryonic eye, (adult:) eye, Jurkat T-cells [1].
CN (adult:) liver, heart, testis, ovary, cortex [1].
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FF Six-6 haploinsufficiency is probably responsible for anophthalmia and pituitary anomalies [1];
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MX M01345 V$SIX6_01.
MX M01398 V$SIX6_02.
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DR TRANSPATH: MO000027217.
DR UniProtKB: O95475;
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RN [1]; RE0014452.
RX PUBMED: 10512683.
RA Gallardo M. E., Lopez-Rios J., Fernaud-Espinosa I., Granadino B., Sanz R., Ramos C., Ayuso C., Seller M. J., Brunner H. G., Bovolenta P., Rodriguez de Cordoba S.
RT Genomic cloning and characterization of the human homeobox gene SIX6 reveals a cluster of SIX genes in chromosome 14 and associates SIX6 hemizygosity with bilateral anophthalmia and pituitary anomalies
RL Genomics 61:82-91 (1999).
RN [2]; RE0014529.
RX PUBMED: 10381573.
RA Seo H. C., Curtiss J., Mlodzik M., Fjose A.
RT Six class homeobox genes in drosophila belong to three distinct families and are involved in head development
RL Mech. Dev. 83:127-139 (1999).
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