AC T03282
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ID T03282
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DT 05.05.2000 (created); rio.
DT 24.03.2009 (updated); din.
CO Copyright (C), QIAGEN.
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FA Six-3
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SY HPE2; hSix-3; hSix3; Sine oculis homeobox homolog 3; SIX homeobox 3; Six3.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G005716 SIX3; HGNC: Six3.
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HO sine oculis (Drosophila).
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CL C0006; homeo; 3.1.6.2.1.
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SF Six proteins can be subdivided into three major families on the basis of sequence conservation in their homeo domain and six domain (Six-1/2/11, Six-3/6/7/10, Six-4/5/8) [2];
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FF Six.3 and Prox-1 act antagonistically on regulation of CRYGD/e/f promotors [4];
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MX M01358 V$SIX3_01.
MX M07428 V$SIX3_Q6.
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DR TRANSPATH: MO000027220.
DR PATHODB: MT010768.
DR PATHODB: MT010769.
DR PATHODB: MT010770.
DR PATHODB: MT010771.
DR PATHODB: MT010815.
DR UniProtKB: O95343;
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RN [1]; RE0014457.
RX PUBMED: 10369266.
RA Wallis D. E., Roessler E., Hehr U., Nanni L., Wiltshire T., Richieri-Costa A., Gillessen-Kaesbach G., Zackai E. H., Rommens J., Muenke M.
RT Mutations in the homeodomain of the human SIX3 gene cause holoprosencephaly
RL Nat. Genet. 22:196-198 (1999).
RN [2]; RE0014529.
RX PUBMED: 10381573.
RA Seo H. C., Curtiss J., Mlodzik M., Fjose A.
RT Six class homeobox genes in drosophila belong to three distinct families and are involved in head development
RL Mech. Dev. 83:127-139 (1999).
RN [3]; RE0016142.
RX PUBMED: 11039582.
RA Pasquier L., Dubourg C., Blayau M., Lazaro L., Le Marec B., David V., Odent S.
RT A new mutation in the six-domain of SIX3 gene causes holoprosencephaly.
RL Eur. J. Hum. Genet. 8:797-800 (2000).
RN [4]; RE0023150.
RX PUBMED: 11139622.
RA Lengler J., Krausz E., Tomarev S., Prescott A., Quinlan R. A., Graw J.
RT Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter.
RL Nucleic Acids Res. 29:515-526 (2001).
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