AC T03292
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ID T03292
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DT 09.05.2000 (created); rio.
DT 08.05.2013 (updated); asv.
CO Copyright (C), QIAGEN.
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FA Six-1
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SY hSix-1; hSix1; Six1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004020 SIX1; HGNC: Six1.
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HO sine oculis (Drosophila).
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CL C0006; homeo; 3.1.6.1.1.
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SF protein sequence has 98% similarity to the murine Six-1 [1];
SF Six proteins can be subdivided into three major families on the basis of sequence conservation in their homeo domain and six domain (Six-1/2/11, Six-3/6/7/10, Six-4/5/8) [2];
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CP from CS17 on: nervous system (DRG, sympathetic ganglia, nerves); CS10: in the cytoplasm of myogenin and titin-expressing cells; CS13:in the nucleus [3].
EX brain,,,adult; none; Northern blot; RNA (undefined); [1].
EX heart,,,adult; none; Northern blot; RNA (undefined); [1].
EX kidney (right and left),,,adult; none; Northern blot; RNA (undefined); [1].
EX liver,,,adult; none; Northern blot; RNA (undefined); [1].
EX lung (right and left),,,adult; none; Northern blot; RNA (undefined); [1].
EX muscles,,,adult; very high; Northern blot; RNA (undefined); [1].
EX pancreas,,,adult; none; Northern blot; RNA (undefined); [1].
EX placenta,,,adult; none; Northern blot; RNA (undefined); [1].
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MX M01313 V$SIX1_01.
MX M07335 V$SIX1_Q3.
MX M07466 V$SIX1_Q3_01.
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BS R55938.
BS R55853.
BS R55856.
BS R28646.
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DR TRANSPATH: MO000027230.
DR UniProtKB: Q15475;
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RN [1]; RE0014473.
RX PUBMED: 8617500.
RA Boucher C. A., Carey N., Edwards Y. H., Siciliano M. J., Johnson K. J.
RT Cloning of the human SIX1 gene and its assignment to chromosome 14
RL Genomics 33:140-142 (1996).
RN [2]; RE0014529.
RX PUBMED: 10381573.
RA Seo H. C., Curtiss J., Mlodzik M., Fjose A.
RT Six class homeobox genes in drosophila belong to three distinct families and are involved in head development
RL Mech. Dev. 83:127-139 (1999).
RN [3]; RE0036083.
RX PUBMED: 12500905.
RA Fougerousse F., Durand M., Lopez S., Suel L., Demignon J., Thornton C., Ozaki H., Kawakami K., Barbet P., Beckmann J. S., Maire P.
RT Six and Eya expression during human somitogenesis and MyoD gene family activation.
RL J. Muscle Res. Cell. Motil. 23:255-264 (2002).
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