AC T03421
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ID T03421
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DT 08.06.2000 (created); rio.
DT 15.07.2008 (updated); tgo.
CO Copyright (C), QIAGEN.
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FA HB9
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SY HB-9; HLXB9.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006208 Mnx1.
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CL C0006; homeo; 3.1.1.13.1.
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SF in mice knockouts the dorsal lobe of the pancreas fails to develop, islets are smaller and have an approx. 20% decrease in number of insulin producing beta cells but a 3-fold increase in number of somatostatin producing delta cells [1] [2];
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CP (embryo 8 days:) notochord, dorsal gut endoderm, ventral endoderm, (embryo 9.5 days:) pancreatic buds, notochord, (embryo 10.5 days:) dorsal pancreatic bud, (embryo 17.5 days:) beta cells, (adult:) beta cells [2].
CN (embryo 17.5 days - adult:) beta and delta cells [2]; (adult:) exocrine pancreas [1] [1] [2].
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FF specification and development of the dorsal pancreatic lobe not ventral pancreatic lobe [1] [2];
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MX M01349 V$HB9_01.
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DR TRANSPATH: MO000027357.
DR UniProtKB: Q9QZW9;
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RN [1]; RE0014572.
RX PUBMED: 10471502.
RA Harrison K. A., Thaler J., Pfaff S. L., Gu H., Kehrl J. H.
RT Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice
RL Nat. Genet. 23:71-75 (1999).
RN [2]; RE0014573.
RX PUBMED: 10471501.
RA Li H., Arber S., Jessell T. M., Edlund H.
RT Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9
RL Nat. Genet. 23:67-70 (1999).
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