AC T03461
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ID T03461
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DT 19.06.2000 (created); rio.
DT 16.02.2015 (updated); pro.
CO Copyright (C), QIAGEN.
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FA Crx
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SY cone rod homeobox protein.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005955 Crx.
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CL C0006; homeo; 3.1.3.17.3.
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SF Crx homeo domain ist 88% and 87% identical to the human Otx-1 and Otx-2 homeo domains [2];
SF Crx deficient mice do not elaborate photoreceptor outer segments, lack rod and cone activity, have altered expression od several photoreceptor- and pineal-specific genes and are affected in circadian entrainment [1];
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CP (embryo day 12.5:) neuroepithelium, (embryo day 14.5-20.5 days:) ventricular zone adjacent to the developing retinal pigment epithelium, (adult:) outer and inner nuclear layer [2]; rods and cones of retina, pinealocytes of pineal gland [2] [1] [1] [2].
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FF transactivates photoreceptor cell-specific genes [2];
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MX M01436 V$CRX_02.
MX M07081 V$CRX_05.
MX M00623 V$CRX_Q4.
MX M01712 V$CRX_Q4_01.
MX M07352 V$CRX_Q4_02.
MX M08892 V$CRX_Q6.
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BS R15733.
BS R09106.
BS R41514.
BS R41516.
BS R66271.
BS R66272.
BS R33359.
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DR TRANSPATH: MO000027397.
DR UniProtKB: O54751;
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RN [1]; RE0014626.
RX PUBMED: 10581037.
RA Furukawa T., Morrow E. M., Li T., Davis F. C., Cepko C. L.
RT Retinopathy and attenuated circadian entrainment in Crx-deficient mice
RL Nat. Genet. 23:466-470 (1999).
RN [2]; RE0014673.
RX PUBMED: 9390516.
RA Chen S., Wang Q. L., Nie Z., Sun H., Lennon G., Copeland N. G., Gilbert D. J., Jenkins N. A., Zack D. J.
RT Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes
RL Neuron 19:1017-1030 (1997).
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