TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T03461 XX ID T03461 XX DT 19.06.2000 (created); rio. DT 16.02.2015 (updated); pro. CO Copyright (C), QIAGEN. XX FA Crx XX SY cone rod homeobox protein. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G005955 Crx. XX CL C0006; homeo; XX SF Crx homeo domain ist 88% and 87% identical to the human Otx-1 and Otx-2 homeo domains [2]; SF Crx deficient mice do not elaborate photoreceptor outer segments, lack rod and cone activity, have altered expression od several photoreceptor- and pineal-specific genes and are affected in circadian entrainment [1]; XX CP (embryo day 12.5:) neuroepithelium, (embryo day 14.5-20.5 days:) ventricular zone adjacent to the developing retinal pigment epithelium, (adult:) outer and inner nuclear layer [2]; rods and cones of retina, pinealocytes of pineal gland [2] [1] [1] [2]. XX FF transactivates photoreceptor cell-specific genes [2]; XX MX M01436 V$CRX_02. MX M07081 V$CRX_05. MX M00623 V$CRX_Q4. MX M01712 V$CRX_Q4_01. MX M07352 V$CRX_Q4_02. MX M08892 V$CRX_Q6. XX BS R15733. BS R09106. BS R41514. BS R41516. BS R66271. BS R66272. BS R33359. XX DR TRANSPATH: MO000027397. DR UniProtKB: O54751; XX RN [1]; RE0014626. RX PUBMED: 10581037. RA Furukawa T., Morrow E. M., Li T., Davis F. C., Cepko C. L. RT Retinopathy and attenuated circadian entrainment in Crx-deficient mice RL Nat. Genet. 23:466-470 (1999). RN [2]; RE0014673. RX PUBMED: 9390516. RA Chen S., Wang Q. L., Nie Z., Sun H., Lennon G., Copeland N. G., Gilbert D. J., Jenkins N. A., Zack D. J. RT Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes RL Neuron 19:1017-1030 (1997). XX //