AC T03478
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ID T03478
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DT 22.06.2000 (created); rio.
DT 17.07.2008 (updated); tgo.
CO Copyright (C), QIAGEN.
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FA Esx-1a
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SY Epx; Esx-1; Esx1; Spx-1; Spx1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014354 Esx1.
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CL C0006; homeo.
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SZ 382 AA; 43.5 kDa (cDNA) (calc.).
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SQ MESHKKCPCCYCTDLKTFVGAVKEETLQDPQPSLSSTLLEGADYQENAESETTFYSDFGA
SQ SPKEEEVEMENSLFNSMFLEEANYQEPEGFEPSRGEAAAPVAEAPQAWNGNENLGGGFLE
SQ SNAQLGEADAAPVRQSLMRPLMQPVAQSSPQPLPANPLQAPQQPEEQEEEEEEQPGEEQP
SQ QQEPKPRRYRICFTPIQLQELEAFFQRVQYPDLFARVELARRLGLPEPRVQVWFQNRRAK
SQ WRRLRRAQAFRNMVPVAMSPPVGVYLDDHYGPIPIVEVIWKCYPMVPRPMHPQMMPLPPR
SQ PPPGFRMPPPFRPPPLPPFPWPPVPPDAHIPNAAREYNPFPFPFPFPFPFPNPFPNPNPN
SQ PNPNPNPNPNPNQNFAGPRYRY
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SC translated from EMBL #AF017735
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FT 184 244 
PS50071; HOMEOBOX_2.
FT 186 242 
PS50552; PAX.
FT 186 248 
SM00389; HOX_1.
FT 187 243 
PF00046; Homeobox domain.
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SF heterozygous female mice that inherited a mutant Esx-1 allele exhibit fetal growth retardation because of vascularization abnormalities and overgrowth in the labyrinth layer of the placenta [1];
SF two splice variants: Esx-1a transcript is more abundant in the testis and Esx-1b is more abundant in the placenta [2];
SF subcellular localization primarily cytoplasmic [2];
SF PF/PN motif inhibits DNA binding activity and nuclear localization [2];
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CP (embryo 7.75 days:) chorionic ectoderm, (embryo 8.5-12.5 days:) ectoplacental plate, labyrinth layer of placenta [1]; (adult:) testis (spermatogonia, preleptotene spermatocytes, round spermatids stage IV-VII) [3] [1] [3].
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FF may play a role in the regulation of spermatogenesis [3];
FF imprinted regulator of placental development and trophoblast differentiation [1];
FF probably involved in signaling interactions mediated through protein-protein interactions [2];
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MX M01474 V$ESX1_01.
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BS R09067.
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DR TRANSPATH: MO000027414.
DR EMBL: AF017735;
DR UniProtKB: O88933;
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RN [1]; RE0014651.
RX PUBMED: 9806555.
RA Li Y., Behringer R. R.
RT Esx1 is an X-chromosome-imprinted regulator of placental development and fetal growth
RL Nat. Genet. 20:309-311 (1998).
RN [2]; RE0014657.
RX PUBMED: 10611245.
RA Yan Y. T., Stein S. M., Ding J., Shen M. M., Abate-Shen C.
RT A novel PF/PN motif inhibits nuclear localization and DNA binding activity of the ESX1 homeoprotein
RL Mol. Cell. Biol. 20:661-671 (2000).
RN [3]; RE0014658.
RX PUBMED: 9256347.
RA Branford W. W., Zhao G. Q., Valerius M. T., Weinstein M., Birkenmeier E. H., Rowe L. B., Potter S. S.
RT Spx1, a novel X-linked homeobox gene expressed during spermatogenesis
RL Mech. Dev. 65:87-98 (1997).
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