AC T03541
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ID T03541
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DT 07.07.2000 (created); hom.
DT 29.11.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA Rfx1p
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SY CRT1; rfx1p; YLR176C.
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OS yeast, Saccharomyces cerevisiae
OC Eukaryota; Fungi; Ascomycota; Hemiascomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
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GE G004091 RFX1.
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SZ 811 AA; 90.6 kDa (cDNA) (calc.).
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SQ MVIFKERKPTENLFTRKIPAKYFIFSPSFLSVHYFEFYLPMSGDNNIEPTSRGSNDNSNG
SQ PSNGSSVNSNRYSLNAPKYSSQPPPASHTYLPPMSVNIPPIASKSSSIYSLLHQSSPRPE
SQ TPNPILPPLIGSGPGSHKPSPTPTQPPAQPATQRQPATYSVYPASISLNRSNSSAYPLSF
SQ KSEETLNNNPPTAAKRTNTFPSIPSSTKKQKTSQEKRISSISRRNTQEIIAKQIAENNKS
SQ KTIEEYAQIVKHAEIKVLSMDSQNTSKAALQLAEQNRERERQVFALLWLMKNCKSQHDSY
SQ VPRGKIFAQYASSCSQNNLKPLSQASLGKLIRTVFPDLTTRRLGMRGQSKYHYCGLKLTV
SQ NESGSVSLNNNNASLSLVHNNDPISPLSSPSPSSPSPQVPNVSSPFSLNRKSLSRTGSPV
SQ KQSSNDNPNEPELESQHPNETEANKLDSLPPAANNPTGTLSSDELTFTHDLIEKVFNCND
SQ KLSDNYNTQILSNTEHPLLTSYKLDFPKIPAGVLPTDTDSDVISSLESLYHIHCNSVYEC
SQ IKFLKSDNISNALFFSNSNSISPTMFNLFISEPLIDWVTKCDLITYTGLIKFFSQFIIHS
SQ NEISDSIIQKLESMIKLLPEQINKAVLELPKALVQRKLSIINNFTKLVKKLIKLLKFILN
SQ FLKSFPIFKSGMNNDWKNIVNLDDILEMMINEDDTNSETNTIMQHLQGFCQVFVTKFLNS
SQ SMSVSNDPSVSIECKSLNEMIKDFCSFISLQSKFSCLKLIDCSTRFRNAIIGDISLKSNE
SQ NLLSWLFLNNVMGQLLNYCFEVMKFVNGLKV
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SC EMBL #U17246
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FT 73 391 
PF00478; IMP dehydrogenase / GMP reductase dom.
FT 270 350 
PF02257; RFX DNA-binding domain.
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SF Rfx1p contains the highly conserved RFX-type DNA binding motif [1];
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FF encodes a DNA-binding protein that recruits the general repressors Ssn6p and Tup1p to the promoters of damage-inducible genes [2];
FF Rfx1p becomes hyperphosphorylated in response to DNA damage and no longer binds DNA, resulting in transcriptional induction [2];
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MX M01641 F$RFX1_01.
MX M02045 F$RFX1_02.
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BS R12418.
BS R12419.
BS R12410.
BS R12411.
BS R12413.
BS R12414.
BS R12415.
BS R12416.
BS R12417.
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DR EMBL: U17246;
DR UniProtKB: P48743; RFX1_YEAST.
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RN [1]; RE0014768.
RX PUBMED: 8600444.
RA Emery P., Durand B., Mach B., Reith W.
RT RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom
RL Nucleic Acids Res. 24:803-807 (1996).
RN [2]; RE0014769.
RX PUBMED: 9741624.
RA Huang M., Zhou Z., Elledge S. J.
RT The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor
RL Cell 94:595-605 (1998).
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