AC T03929
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ID T03929
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DT 12.10.2000 (created); rio.
DT 16.11.2007 (updated); jag.
CO Copyright (C), QIAGEN.
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FA Barx-2
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G001922 Barx2.
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HO BarH1T03926, BarH2T03927 (Drosophila).
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CL C0006; homeo.
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SZ 228 AA; 25.2 kDa (cDNA) (calc.), 66 kDa (SDS) [1]
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SQ MIDEILSKETCDYFEKLSLYSVCPSLVVRPKPLHSCTGSPSLRAYPLPSVITRQPTVISH
SQ LVPTGSGLTPVLTRHPVAAAEAAAAAAETPGGEALASSESETEQPTPRQKKPRRSRTIFT
SQ ELQLMGLEKKFQKQKYLSTPDRLDLAQSLGLTQLQVKTWYQNRRMKWKKMVLKGGQEAPT
SQ KPKGRPKKNSIPTSEEIEAEEKMNSQAQSQELLESSEREASSEPPPLS
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SC translated from EMBL #L77900
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FT 108 114 
basic hexapeptide, resembles nuclear localization signal [1].
FT 110 170 
PS50071; HOMEOBOX_2.
FT 112 174 
SM00389; HOX_1.
FT 113 169 
PF00046; Homeobox domain.
FT 179 194 
basic domain [1].
FT 195 201 
acidic domain [1].
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SF 87% identity to murine Barx1 T02403 homeo domain [1];
SF expression pattern overlaps with Barx1 T02403, for detailed expression pattern see [1];
SF the 17-amino acid Barx Basic Region(BBR) is required for Barx-2 binding to the homeodomain binding sites of L1, Ng-CAM, and N-CAM [2];
SF interacts with factors CREB1 and ATF-2 [2];
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EX Rathke's pouch,,,Theiler Stage 19; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX dorsal root ganglion,,,Theiler Stage 17; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX ectodermal infoldings of the eye,,,Theiler Stage 17; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX first pharyngeal pouch,,,Theiler Stage 17; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX floor plate of diencephalon,,,Theiler Stage 19; high; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX forelimb bud,,,Theiler Stage 17; low; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX forelimb bud,,,Theiler Stage 19; low; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX forelimb bud,mesenchyme cell,,Theiler Stage 19; low; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX frontonasal process,,,Theiler Stage 19; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX future mesencephalon,,,Theiler Stage 15; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX hindlimb bud,,,Theiler Stage 17; low; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX mantle layer of mesencephalon,,,Theiler Stage 19; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX mantle layer of telencephalon,,,Theiler Stage 19; medium; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX precartilaginous condensations of the forelimb,,,Theiler Stage 17; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX rhombencephalon,,,Theiler Stage 19; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX rhombencephalon,,,Theiler Stage 20; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX spinal cord,,,Theiler Stage 17; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX telencephalon,,,Theiler Stage 15; high; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX telencephalon,,,Theiler Stage 19; low; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
EX telencephalon,,,Theiler Stage 20; detectable; RNA-in situ hybridization (non-radioactive); RNA (undefined); [1].
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FF can act as repressor and activator [1] [2];
FF activation of CAM L1 (cell adhesion molecule) gene expression [1];
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MX M01431 V$BARX2_01.
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BS R09450.
BS R16312.
BS R01678.
BS R01679.
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DR TRANSPATH: MO000027839.
DR EMBL: L77900;
DR UniProtKB: O08686;
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RN [1]; RE0015165.
RX PUBMED: 9122247.
RA Jones F. S., Kioussi C., Copertino D. W., Kallunki P., Holst B. D., Edelman G. M.
RT Barx2, a new homeobox gene of the Bar class, is expressed in neural and craniofacial structures during development
RL Proc. Natl. Acad. Sci. USA 94:2632-2637 (1997).
RN [2]; RE0025138.
RX PUBMED: 10781615.
RA Edelman D. B., Meech R., Jones F. S.
RT The homeodomain protein Barx2 contains activator and repressor domains and interacts with members of the CREB family.
RL J. Biol. Chem. 275:21737-21745 (2000).
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