AC T03983
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ID T03983
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DT 27.10.2000 (created); mpr.
DT 13.01.2015 (updated); spk.
CO Copyright (C), QIAGEN.
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FA AML3-isoform2
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SY CBF-alpha 1; CBFA1; Osf2; PEBP2alpha1; PEBP2alphaA; RUNX2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G005051 RUNX2; HGNC: RUNX2.
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CL C0029; runt; 6.4.1.0.1.2.
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SZ 507 AA; 55.0 kDa (cDNA) (calc.).
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SQ MRIPVDPSTSRRFSPPSSSLQPGKMSDVSPVVAAQQQQQQQQQQQQQQQQQQQQQQQEAA
SQ AAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNK
SQ TLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRG
SQ KSFTLTITVFTNPPQVATYHRAIKVTVDGPREPRRHRQKLDDSKPSLFSDRLSDLGRIPH
SQ PSMRVGVPPQNPRPSLNSAPSPFNPQGQSQITDPRQAQSSPPWSYDQSYPSYLSQMTSPS
SQ IHSTTPLSSTRGTGLPAITDVPRRISDDDTATSDFCLWPSTLSKKSQAGASELGPFSDPR
SQ QFPSISSLTESRFSNPRMHYPATFTYTPPVTSGMSLGMSATTHYHTYLPPPYPGSSQSQS
SQ GPFQTSSTPYLYYGTSSGSYQFPMVPGGDRSPSRMLPPCTTTSNGSTLLNPNLPNQNDGV
SQ DADGSHSSSPTVLNSSGRMDESVWRPY
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SC Swiss-Prot#Q13950-2
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FT 85 219 
PF00853; Runt domain.
FT 87 215 
PS51062; RUNT.
FT 382 408 
putative nuclear matrix targeting signal [2].
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SF factor was found to be associated with the nuclear matrix [2];
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FF related to human cleidocranial dysplasia (CCD) [1];
FF mapped to chromosome region 6p21 [1];
FF essential for skeletal morphogenesis [1];
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MX M07276 V$AML3_Q3.
MX M08866 V$AML_Q4.
MX M00769 V$AML_Q6.
MX M00731 V$OSF2_Q6.
MX M00984 V$PEBP_Q6.
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DR TRANSPATH: MO000027893.
DR EMBL: AF001450; RUNX2_HUMAN.
DR UniProtKB: Q13950-2;
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RN [1]; RE0005889.
RX PUBMED: 9182765.
RA Mundlos S., Otto F., Mundlos C., Mulliken J. B., Aylsworth A. S., Albright S., Lindhout D., Cole W. G., Henn W., Knoll J. H. M., Owen M. J., Mertelsmann R., Zabel B. U., Olsen B. R.
RT Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia
RL Cell 89:773-779 (1997).
RN [2]; RE0006488.
RX PUBMED: 9192636.
RA Zeng C., van Wijnen A. J., Stein J. L., Meyers S., Sun W., Shopland L., Lawrence J. B., Penman S., Lian J.B., Stein G. S., Hiebert S. W.
RT Identification of a nuclear matrix targeting signal in leukemia and bone-related AML/CBF-alpha transcription factors
RL Proc. Natl. Acad. Sci. USA 94:6746-6751 (1997).
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//