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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T04012 XX ID T04012 XX DT 21.11.2000 (created); rio. DT 20.11.2007 (updated); sba. CO Copyright (C), QIAGEN. XX FA Alx-4 XX SY aristaless homeobox like 4. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G002044 ALX4; HGNC: Alx4. XX CL C0006; homeo; 3.1.3.1.3. XX SF OAR domain (initials of Otp, Aristaless and Rax) is a conserved region C-terminal of the homeo domain [1]; XX CP bone [2]. XX FF mutation (haploinsufficiency) causes parietal foramina (PFM) or Potocki-Shaffer syndrome (oval defects of the parietal bones) [2] [3]; FF involved in skull ossification [3]; XX MX M00619 V$ALX4_01. MX M01417 V$ALX4_02. XX DR TRANSPATH: MO000027921. DR UniProtKB: Q9H161; XX RN [1]; RE0014693. RX PUBMED: 9096350. RA Furukawa T., Kozak C. A., Cepko C. L. RT rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina RL Proc. Natl. Acad. Sci. USA 94:3088-3093 (1997). RN [2]; RE0015330. RX PUBMED: 11017806. RA Wu Y. Q., Badano J. L., McCaskill C., Vogel H., Potocki L., Shaffer L. G. RT Haploinsufficiency of ALX4 as a Potential Cause of Parietal Foramina in the 11p11.2 Contiguous Gene-Deletion Syndrome RL Am. J. Hum. Genet. 67:1327-1332 (2000). RN [3]; RE0015552. RX PUBMED: 11137991. RA Mavrogiannis L. A., Antonopoulou I., Baxova A., Kutilek S., Kim C. A., Sugayama S. M., Salamanca A., Wall S. A., Morriss-Kay G. M., Wilkie A. O. RT Haploinsufficiency of the human homeobox gene ALX4 causes skull ossification defects RL Nat. Genet. 27:17-18 (2001). XX //