AC T04145
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ID T04145
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DT 02.01.2001 (created); rio.
DT 08.08.2012 (updated); pos.
CO Copyright (C), QIAGEN.
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FA WSTF
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SY BAZ1B; bromodomain adjacent to zinc finger domain, 1B; WBSCR10; WBSCR9; Williams syndrome transcription factor; WSTF.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002145 BAZ1B; HGNC: BAZ1B.
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CL C0034; zin.
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SF WSTF gene is deleted in Williams syndrome [1];
SF the PHD finger in WSTF is a metal-dependent folding motif that binds two zinc atoms, shares structural similarities with RING and FYVE zinc finger domains and is most likely involved in protein-protein inaction and gene silencing [2];
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EX blood,basophil granulocyte,Circulatory System & Hematopoietic System,adult; low; Northern blot; mRNA (poly-A); [1].
EX blood,eosinophil granulocyte,Circulatory System & Hematopoietic System,adult; low; Northern blot; mRNA (poly-A); [1].
EX blood,lymphocyte,Circulatory System & Hematopoietic System,adult; low; Northern blot; mRNA (poly-A); [1].
EX blood,monocyte,Circulatory System & Hematopoietic System,adult; low; Northern blot; mRNA (poly-A); [1].
EX blood,neutrophil granulocyte,Circulatory System & Hematopoietic System,adult; low; Northern blot; mRNA (poly-A); [1].
EX brain,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX brain,,,fetal; high; Northern blot; mRNA (poly-A); [1].
EX colon,,,adult; medium; Northern blot; mRNA (poly-A); [1].
EX heart,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX kidney (right and left),,,adult; medium; Northern blot; mRNA (poly-A); [1].
EX kidney (right and left),,,fetal; high; Northern blot; mRNA (poly-A); [1].
EX liver,,,adult; low; Northern blot; mRNA (poly-A); [1].
EX liver,,,fetal; high; Northern blot; mRNA (poly-A); [1].
EX lung (right and left),,,adult; low; Northern blot; mRNA (poly-A); [1].
EX lung (right and left),,,fetal; high; Northern blot; mRNA (poly-A); [1].
EX muscles,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX ovary (right and left),,,adult; high; Northern blot; mRNA (poly-A); [1].
EX pancreas,,,adult; medium; Northern blot; mRNA (poly-A); [1].
EX placenta,,,adult; high; Northern blot; mRNA (poly-A); [1].
EX prostate gland,,,adult; low; Northern blot; mRNA (poly-A); [1].
EX small intestine,,,adult; medium; Northern blot; mRNA (poly-A); [1].
EX spleen,,,adult; medium; Northern blot; mRNA (poly-A); [1].
EX testis (right and left),,,adult; low; Northern blot; mRNA (poly-A); [1].
EX thymus,,,adult; low; Northern blot; mRNA (poly-A); [1].
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FF probably involved in Williams syndrome (congenital vascular and heart disease, dysmorphic facial features, growth deficiency, infantile hypercalcemia, mental retardation, unique cognitive profile and characteristic personality) [1];
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IN T05452 BAF155; human, Homo sapiens.
IN T22426 BAF170; human, Homo sapiens.
IN T05451 BRG1; human, Homo sapiens.
IN T04550 CSB; human, Homo sapiens.
IN T17241 DEK; human, Homo sapiens.
IN T05875 p160MBP; human, Homo sapiens.
IN T22463 SNF2H; human, Homo sapiens.
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DR TRANSPATH: MO000028047.
DR UniProtKB: Q9UIG0;
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RN [1]; RE0015526.
RX PUBMED: 9828126.
RA Lu X., Meng X., Morris C. A., Keating M. T.
RT A novel human gene, WSTF, is deleted in Williams syndrome
RL Genomics 54:241-249 (1998).
RN [2]; RE0015527.
RX PUBMED: 11124022.
RA Pascual J., Martinez-Yamout M., Dyson H. J., Wright P. E.
RT Structure of the PHD zinc finger from human williams-beuren syndrome transcription factor
RL J. Mol. Biol. 304:723-729 (2000).
RN [3]; RE0071073.
RX PUBMED: 16603771.
RA Cavellan E., Asp P., Percipalle P., Farrants A. K.
RT The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription.
RL J. Biol. Chem. 281:16264-16271 (2006).
RN [4]; RE0071087.
RX PUBMED: 16514417.
RA Percipalle P., Fomproix N., Cavellan E., Voit R., Reimer G., Kruger T., Thyberg J., Scheer U., Grummt I., Farrants A. K.
RT The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription.
RL EMBO Rep. 7:525-530 (2006).
RN [5]; RE0071328.
RX PUBMED: 11980720.
RA Bozhenok L., Wade P. A., Varga-Weisz P.
RT WSTF-ISWI chromatin remodeling complex targets heterochromatic replication foci.
RL EMBO J. 21:2231-2241 (2002).
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