AC T04155
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ID T04155
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DT 05.01.2001 (created); rio.
DT 14.11.2007 (updated); sba.
CO Copyright (C), QIAGEN.
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FA HCV-NS5A-1A-H
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SY HCV non structural protein 5A isolate H; HCV NS5A H isolate; Hepatitis C virus NS5A H isolate.
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OS HCV, Hepatitis C virus Genotype 1A isolate H
OC Viruses; ssRNA positive-strand viruses, no DNA stage; Flaviviridae; Hepacivirus; Hepatitis C virus; Hepatitis C virus genotype 1; Hepatitis C virus subtype 1a
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SF interaction with SRCAP T04151 enforces the transcriptional repression [1];
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FF negative regulator on the p21 promoter in favor of promoting cell growth [1];
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IN T02455 pitx1; human, Homo sapiens.
IN T10327 pitx1; human, Homo sapiens.
IN T04151 SRCAP; human, Homo sapiens.
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DR TRANSPATH: MO000028054.
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RN [1]; RE0015539.
RX PUBMED: 10702287.
RA Ghosh A. K., Majumder M., Steele R., Yaciuk P., Chrivia J., Ray R., Ray R. B.
RT Hepatitis C virus NS5A protein modulates transcription through a novel cellular transcription factor SRCAP
RL J. Biol. Chem. 275:7184-7188 (2000).
RN [2]; RE0048985.
RX PUBMED: 16844119.
RA Wang J., Tong W., Zhang X., Chen L., Yi Z., Pan T., Hu Y., Xiang L., Yuan Z.
RT Hepatitis C virus non-structural protein NS5A interacts with FKBP38 and inhibits apoptosis in Huh7 hepatoma cells.
RL FEBS Lett. 580:4392-4400 (2006).
RN [3]; RE0048989.
RX PUBMED: 16731940.
RA Yu G. Y., Lee K. J., Gao L., Lai M. M.
RT Palmitoylation and polymerization of hepatitis C virus NS4B protein.
RL J. Virol. 80:6013-6023 (2006).
RN [4]; RE0049007.
RX PUBMED: 16405965.
RA Burckstummer T., Kriegs M., Lupberger J., Pauli E. K., Schmittel S., Hildt E.
RT Raf-1 kinase associates with Hepatitis C virus NS5A and regulates viral replication.
RL FEBS Lett. 580:575-580 (2006).
RN [5]; RE0049480.
RX PUBMED: 11278402.
RA Arima N., Kao C. Y., Licht T., Padmanabhan R., Sasaguri Y., Padmanabhan R.
RT Modulation of cell growth by the hepatitis C virus nonstructural protein NS5A.
RL J. Biol. Chem. 276:12675-12684 (2001).
RN [6]; RE0049547.
RX PUBMED: 9409782.
RA Ide Y., Tanimoto A., Sasaguri Y., Padmanabhan R.
RT Hepatitis C virus NS5A protein is phosphorylated in vitro by a stably bound protein kinase from HeLa cells and by cAMP-dependent protein kinase A-alpha catalytic subunit.
RL Gene 201:151-158 (1997).
RN [7]; RE0049557.
RX PUBMED: 10488152.
RA Reed K. E., Rice C. M.
RT Identification of the major phosphorylation site of the hepatitis C virus H strain NS5A protein as serine 2321.
RL J. Biol. Chem. 274:28011-28018 (1999).
RN [8]; RE0049593.
RX PUBMED: 12620797.
RA Ghosh A. K., Majumder M., Steele R., Ray R., Ray R. B.
RT Modulation of interferon expression by hepatitis C virus NS5A protein and human homeodomain protein PTX1.
RL Virology 306:51-59 (2003).
RN [9]; RE0049596.
RX PUBMED: 15063116.
RA Sarcar B., Ghosh A. K., Steele R., Ray R., Ray R. B.
RT Hepatitis C virus NS5A mediated STAT3 activation requires co-operation of Jak1 kinase.
RL Virology 322:51-60 (2004).
RN [10]; RE0049651.
RX PUBMED: 17166835.
RA Quintavalle M., Sambucini S., Summa V., Orsatti L., Talamo F., de Francesco R., Neddermann P.
RT Hepatitis C virus NS5A is a direct substrate of casein kinase I-alpha, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitors.
RL J. Biol. Chem. 282:5536-5544 (2007).
RN [11]; RE0049775.
RX PUBMED: 9311791.
RA Reed K. E., Xu J., Rice C. M.
RT Phosphorylation of the hepatitis C virus NS5A protein in vitro and in vivo: properties of the NS5A-associated kinase.
RL J. Virol. 71:7187-7197 (1997).
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