AC T04232
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ID T04232
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DT 24.01.2001 (created); dkl.
DT 30.07.2014 (updated); msr.
CO Copyright (C), QIAGEN.
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FA Smad2
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SY Smad-2.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002369 Smad2.
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CL C0041; SMAD; 7.1.1.1.2.
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SF MH2 domain contains a central beta sandwich, with a three helix bundle (H3, H4, H5) and a single strand (B1�) on one end, and a loop-helix region (L1, L2, L3, H1) on the other end [3];
SF specific interaction of five AAs (N381, W368, Y366, I341, F346) with SARA [3];
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IN T02441 AML3; rat, Rattus norvegicus.
IN T14202 GKLF; Mammalia.
IN T15112 GKLF; rat, Rattus norvegicus.
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MX M03580 V$SMAD2_Q6.
MX M08897 V$SMAD_Q4.
MX M00792 V$SMAD_Q6.
MX M00974 V$SMAD_Q6_01.
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BS R31183.
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DR TRANSPATH: MO000020650.
DR UniProtKB: O70436; O70436.
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RN [1]; RE0015115.
RX PUBMED: 10767528.
RA Dick A., Mayr T., Bauer H., Meier A., Hammerschmidt M.
RT Cloning and characterization of zebrafish smad2, smad3 and smad4
RL Gene 246:69-80 (2000).
RN [2]; RE0015631.
RA Miyakita A., Okuno S., Watanabe T. K., Oga K., Tsuji A., Hishigaki H., Kato S., Sano A., Suto T., Nakagawa K., Nakahara Y., Haraguchi N., Higashi K.
RT Molecular cloning of rat Smad2 gene
RL direct submission (EMBL) : ().
RN [3]; RE0016216.
RX PUBMED: 10615055.
RA Wu G., Chen Y. G., Ozdamar B., Gyuricza C. A., Chong P. A., Wrana J. L., Massague J., Shi Y.
RT Structural basis of Smad2 recognition by the Smad anchor for receptor activation.
RL Science 287:92-97 (2000).
RN [4]; RE0035990.
RX PUBMED: 14982932.
RA Selvamurugan N., Kwok S., Alliston T., Reiss M., Partridge N. C.
RT Transforming growth factor-beta 1 regulation of collagenase-3 expression in osteoblastic cells by cross-talk between the Smad and MAPK signaling pathways and their components, Smad2 and Runx2.
RL J. Biol. Chem. 279:19327-19334 (2004).
RN [5]; RE0049335.
RX PUBMED: 15153551.
RA Dai C., Liu Y.
RT Hepatocyte growth factor antagonizes the profibrotic action of TGF-beta1 in mesangial cells by stabilizing Smad transcriptional corepressor TGIF.
RL J. Am. Soc. Nephrol. 15:1402-1412 (2004).
RN [6]; RE0052119.
RX PUBMED: 16314499.
RA Zhu Q., Pearson-White S., Luo K.
RT Requirement for the SnoN oncoprotein in transforming growth factor beta-induced oncogenic transformation of fibroblast cells.
RL Mol. Cell. Biol. 25:10731-10744 (2005).
RN [7]; RE0053874.
RX PUBMED: 16740974.
RA de Guise C., Lacerte A., Rafiei S., Reynaud R., Roy M., Brue T., Lebrun J. J.
RT Activin inhibits the human Pit-1 gene promoter through the p38 kinase pathway in a Smad-independent manner.
RL Endocrinology 147:4351-4362 (2006).
RN [8]; RE0064277.
RX PUBMED: 17125875.
RA Weng H., Mertens P. R., Gressner A. M., Dooley S.
RT IFN-gamma abrogates profibrogenic TGF-beta signaling in liver by targeting expression of inhibitory and receptor Smads.
RL J. Hepatology 46:295-303 (2007).
RN [9]; RE0064958.
RX PUBMED: 18511507.
RA Chen Y. J., Lee M. T., Yao H. C., Hsiao P. W., Ke F. C., Hwang J. J.
RT Crucial role of estrogen receptor-alpha interaction with transcription coregulators in follicle-stimulating hormone and transforming growth factor beta1 up-regulation of steroidogenesis in rat ovarian granulosa cells.
RL Endocrinology 149:4658-4668 (2008).
RN [10]; RE0067098.
RX PUBMED: 20375011.
RA Li H. X., Han M., Bernier M., Zheng B., Sun S. G., Su M., Zhang R., Fu J. R., Wen J. K.
RT Kruppel-like factor 4 promotes differentiation by transforming growth factor-beta receptor-mediated Smad and p38 MAPK signaling in vascular smooth muscle cells.
RL J. Biol. Chem. 285:17846-17856 (2010).
RN [11]; RE0069194.
RX PUBMED: 21245987.
RA Gressner O. A., Peredniene I., Gressner A. M.
RT Connective tissue growth factor reacts as an IL-6/STAT3-regulated hepatic negative acute phase protein.
RL World J. Gastroenterol. 17:151-163 (2011).
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