AC T04279
XX
ID T04279
XX
DT 01.02.2001 (created); rio.
DT 12.02.2015 (updated); hna.
CO Copyright (C), QIAGEN.
XX
FA FOXP3
XX
SY scurfin (gene); SFN.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G006103 Foxp3.
XX
CL C0023; fork head; 3.3.1.16.3.
XX
SF 94% and 86% fork head domain similarity and overall amino acid similarity to human FOXP3 T04280 [1];
SF associated with the X-linked scurfy (sf) mutation which results in lethality in hemizygous males 16-25 days after birth and is characterized by overproliferation of CD4+CD8- T lymphocytes, extensive multiorgan infiltration and elevation of numerous cytokines [1] [2];
XX
CP (newborn/10 days:) thymus, (adult:) thymus, spleen, lymphoid cells (Th1, Th2, CD4-CD8+ and B220 cells) [1].
CN ((embryo 18 days:) liver, thymus, (newborn/10 days:) brain, heart, liver, kidney, lung, spleen, (adult:) brain, heart, kidney, lung [1].
XX
FF critical for control of immune responses and potentially T-cell number, acting as an apparent rheostat for T-cell activation [1];
XX
MX M01599 V$FOXP3_01.
MX M00992 V$FOXP3_Q4.
MX M07419 V$FOXP3_Q6.
XX
BS R66216.
BS R66218.
XX
DR TRANSPATH: MO000028143.
DR UniProtKB: Q99JB6;
XX
RN [1]; RE0015693.
RX PUBMED: 11138001.
RA Brunkow M. E., Jeffery E. W., Hjerrild K. A., Paeper B., Clark L. B., Yasayko S. A., Wilkinson J. E., Galas D., Ziegler S. F., Ramsdell F.
RT Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.
RL Nat. Genet. 27:68-73 (2001).
RN [2]; RE0015696.
RX PUBMED: 10072494.
RA Clark L. B., Appleby M. W., Brunkow M. E., Wilkinson J. E., Ziegler S. F., Ramsdell F.
RT Cellular and molecular characterization of the scurfy mouse mutant
RL J. Immunol. 162:2546-2554 (1999).
RN [3]; RE0054837.
RX PUBMED: 17570480.
RA Zuo T., Wang L., Morrison C., Chang X., Zhang H., Li W., Liu Y., Wang Y., Liu X., Chan M. W., Liu J. Q., Love R., Liu C. G., Godfrey V., Shen R., Huang T. H., Yang T., Park B. K., Wang C. Y., Zheng P., Liu Y.
RT FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene.
RL Cell 129:1275-1286 (2007).
RN [4]; RE0066051.
RX PUBMED: 19843574.
RA Forward N. A., Furlong S. J., Yang Y., Lin T. J., Hoskin D. W.
RT Signaling through TLR7 enhances the immunosuppressive activity of murine CD4+CD25+ T regulatory cells.
RL J. Leukoc. Biol. 87:117-125 (2010).
XX
//