AC T04313
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ID T04313
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DT 08.02.2001 (created); rio.
DT 15.07.2008 (updated); tgo.
CO Copyright (C), QIAGEN.
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FA HOX11L2
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SY HOX11L2; Rnx (mouse); T cell leukemia homeobox factor 3; Tlx3.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006821 TLX3; HGNC: Tlx3.
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CL C0006; homeo; 3.1.2.21.3.
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SF belongs to the distinct homeobox gene family, together with HOX11 and HOX11L1;
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CP very low level in fetal thymus and spleen, adult thymus [3]; high expression level in childhood T acute lymphoblastic leukemias (T-ALL) [3]; [3].
CN normal adult tissues: spleen, peripheric blood lymphocytes, bone marrow [3].
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FF critical oncogene in childhood T acute lymphoblastic leukemia (T-ALL) [3] [5];
FF activated as a result of translocation t(5,14)(q35,q32) which is present in about 20 percent of T-ALL samples [3] [5];
FF the translocation t(5,14)(q35,q32) leads to juxtaposition with 3 prime end of BCL11B [4];
FF is a marker of leukemic cells [3];
FF belongs to the group of T-cell oncogenes encoding for transcription factors: HOX11, HOX11L1, HOX11L2, TAL1, LYL1, LMO2 [3];
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IN T16551 RBTN2; human, Homo sapiens.
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DR TRANSPATH: MO000028171.
DR UniProtKB: O43711;
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RN [1]; RE0015745.
RA Delgado P., Rodriguez R., Gonzalez-Sarmiento R.
RT Genomic characterization of the human and mouse HOX11L2 genes
RL direct submission (EMBL) : (1998).
RN [2]; RE0023843.
RX PUBMED: 11435718.
RA Lee-Kirsch M. A., Engel K., Paditz E., Rosen-Wolff A., Lee Y. A., Gahr M.
RT Assignment of the human homeobox 11-like 2 gene (HOX11L2) to chromosome 5q34-->q35 by radiation hybrid mapping.
RL Cytogenet. Cell Genet. 92:358 (2001).
RN [3]; RE0023849.
RX PUBMED: 12130513.
RA Ballerini P., Blaise A., Busson-Le Coniat M., Su X. Y., Zucman-Rossi J., Adam M., van den Akker J., Perot C., Pellegrino B., Landman-Parker J., Douay L., Berger R., Bernard O. A.
RT HOX11L2 expression defines a clinical subtype of pediatric T-ALL associated with poor prognosis.
RL Blood 100:991-997 (2002).
RN [4]; RE0023852.
RX PUBMED: 12661009.
RA MacLeod R. A., Nagel S., Kaufmann M., Janssen J. W., Drexler H. G.
RT Activation of HOX11L2 by juxtaposition with 3'-BCL11B in an acute lymphoblastic leukemia cell line (HPB-ALL) with t(5;14)(q35;q32.2).
RL Genes Chromosomes Cancer 37:84-91 (2003).
RN [5]; RE0023853.
RX PUBMED: 12454747.
RA Mauvieux L., Leymarie V., Helias C., Perrusson N., Falkenrodt A., Lioure B., Lutz P., Lessard M.
RT High incidence of Hox11L2 expression in children with T-ALL.
RL Leukemia 16:2417-2422 (2002).
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