AC T04314
XX
ID T04314
XX
DT 08.02.2001 (created); rio.
DT 15.07.2008 (updated); tgo.
CO Copyright (C), QIAGEN.
XX
FA Hox11l2
XX
SY HOX11L2; respiratory neuron homeobox factor; Rnx (mouse); T cell leukemia homeobox factor 3; Tlx3.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G006822 Tlx3.
XX
CL C0006; homeo; 3.1.2.21.3.
XX
CP expression is first detected at embryonic stage E10.5 [2]; developing dorsal and ventral region of the medulla oblongata [4]; neurons in developing hindbrain and spinal cord [3]; [2] [3] [4].
XX
FF Rnx/Hox11L2-deficient newborn mice die from a defect in respiratory control [4];
FF is critical for the development of the ventral medullary respiratory center [4];
FF in embryonic neurons, is coexpressed with Phox2b [2];
FF is required for the formation of the brainstem (nor)adrenergic neurons, together with Phox2b and MASH1 [2];
FF together with TLX1/HOX11, is associated with development of somatic sensory neurons and D2/D4 dorsal interneurons [3];
XX
DR TRANSPATH: MO000028172.
DR UniProtKB: O55144;
XX
RN [1]; RE0015745.
RA Delgado P., Rodriguez R., Gonzalez-Sarmiento R.
RT Genomic characterization of the human and mouse HOX11L2 genes
RL direct submission (EMBL) : (1998).
RN [2]; RE0023844.
RX PUBMED: 11581159.
RA Qian Y., Fritzsch B., Shirasawa S., Chen C. L., Choi Y., Ma Q.
RT Formation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is dependent on homeodomain protein Rnx/Tlx3.
RL Genes Dev. 15:2533-2545 (2001).
RN [3]; RE0023846.
RX PUBMED: 12023301.
RA Qian Y., Shirasawa S., Chen C. L., Cheng L., Ma Q.
RT Proper development of relay somatic sensory neurons and D2/D4 interneurons requires homeobox genes Rnx/Tlx-3 and Tlx-1.
RL Genes Dev. 16:1220-1233 (2002).
RN [4]; RE0023847.
RX PUBMED: 10700185.
RA Shirasawa S., Arata A., Onimaru H., Roth K. A., Brown G. A., Horning S., Arata S., Okumura K., Sasazuki T., Korsmeyer S. J.
RT Rnx deficiency results in congenital central hypoventilation.
RL Nat. Genet. 24:287-290 (2000).
XX
//