AC T04337
XX
ID T04337
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DT 20.02.2001 (created); rio.
DT 06.11.2014 (updated); hna.
CO Copyright (C), QIAGEN.
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FA NKX2B
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SY Nkx-2.2; Nkx2-2; NKX2B.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002538 NKX2-2; HGNC: Nkx2-2.
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CL C0053; NK-2/Nkx.
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SZ 273 AA; 30.1 kDa (gene) (calc.).
XX
SQ MSLTNTKTGFSVKDILDLPDTNDEEGSVAEGPEEENEGPEPAKRAGPLGQGALDAVQSLP
SQ LKNPFYDSSDNPYTRWLASTEGLQYSLHGLAAGAPPQDSSSKSPEPSADESPDNDKETPG
SQ GGGDAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHR
SQ YKMKRARAEKGMEVTPLPSPRRVAVPVLVRDGKPCHALKAQDLAAATFQAGIPFSAYSAQ
SQ SLQHMQYNAQYSSASTPQYPTAHPLVQAQQWTW
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SC translated from EMBL #AF019415
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FT 126 186 
PS50071; HOMEOBOX_2.
FT 128 190 
SM00389; HOX_1.
FT 129 185 
PF00046; Homeobox domain.
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SF NK2 domain functions as an intramolecular regulator of the C-terminal activation domain [2];
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MX M00485 V$NKX22_01.
MX M01372 V$NKX22_02.
MX M02109 V$NKX2B_Q3.
MX M07391 V$NKX2B_Q3_01.
XX
BS R11092.
BS R11093.
BS R11094.
BS R11095.
BS R11096.
BS R11097.
BS R11098.
BS R11099.
BS R11100.
BS R11101.
BS R11102.
BS R11103.
BS R11104.
BS R11105.
BS R11106.
BS R11107.
BS R11108.
BS R11109.
BS R11110.
BS R11111.
BS R11112.
BS R11113.
BS R11114.
BS R64707.
BS R16587.
BS R16588.
BS R18138.
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DR TRANSPATH: MO000028195.
DR EMBL: AF019415;
DR UniProtKB: O95096;
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RN [1]; RE0015774.
RX PUBMED: 9703340.
RA Furuta H., Horikawa Y., Iwasaki N., Hara M., Sussel L., Le Beau M. M., Davis E. M., Ogata M., Iwamoto Y., German M. S., Bell G. I.
RT Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese
RL Diabetes 47:1356-1358 (1998).
RN [2]; RE0016875.
RX PUBMED: 10944215.
RA Watada H., Mirmira R. G., Kalamaras J., German M. S.
RT Intramolecular control of transcriptional activity by the NK2-specific domain in NK-2 homeodomain proteins.
RL Proc. Natl. Acad. Sci. USA 97:9443-9448 (2000).
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//