AC T04362
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ID T04362
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DT 27.02.2001 (created); rio.
DT 19.02.2015 (updated); ros.
CO Copyright (C), QIAGEN.
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FA ipf1
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SY glucose sensitive factor; GSF; IDX-1; insulin promoter factor 1; insulin upstream factor 1; IPF-1; islet/duodenum homeobox 1; IUF-1; IUF1; pancreas/duodenum homeobox 1; pancreas/duodenum homeobox-1; Pdx-1; Pdx1; somatostatin transactivating factor-1; STF-1; STF1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002249 PDX1; HGNC: Pdx1.
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CL C0006; homeo; 3.1.1.15.1.
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CP beta cells within the adult endocrine pancreas [13].
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FF regulates pancreatic development and adult islet beta cell function [13];
FF may play a role in tissue-specific control of insulin expression [6];
FF glucose responsive activator of insulin expression [5];
FF critical regulator of pancreas development [10];
FF mutations cause pancreatic agenesis [10];
FF mutations can cause maturity-onset diabetes of the young (MODY) and represent significant risk factors for type 2 diabetes in humans due to reduced binding activity and reduced activation of the insulin gene in response to hypoglycemia [7] [8];
FF glucose increases binding to DNA which is mediated by SAPK2 (stress activated protein kinase 2/mitogen-activated protein kinase p38) turning on a novel ipf1-kinase [5];
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MX M01233 V$IPF1_01.
MX M01234 V$IPF1_02.
MX M01235 V$IPF1_03.
MX M01236 V$IPF1_04.
MX M01255 V$IPF1_05.
MX M01438 V$IPF1_06.
MX M00436 V$IPF1_Q4.
MX M01013 V$IPF1_Q4_01.
MX M02096 V$IPF1_Q5.
MX M04614 V$IPF1_Q5_01.
MX M01275 V$IPF1_Q6.
MX M04425 V$PDX1_06.
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BS R59926.
BS R58508.
BS R17149.
BS R04228.
BS R04225.
BS R04226.
BS R04227.
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DR TRANSPATH: MO000007664.
DR TRANSCOMPEL: C00277.
DR PATHODB: MT010806.
DR PATHODB: MT010807.
DR PATHODB: MT010808.
DR PATHODB: MT010810.
DR PATHODB: MT010811.
DR PATHODB: MT010812.
DR PATHODB: MT010814.
DR PATHODB: MT010829.
DR PATHODB: MT010833.
DR PATHODB: MT010851.
DR UniProtKB: P52945;
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RN [1]; RE0000909.
RX PUBMED: 2186040.
RA Boam D. S. W., Clark A. R., Docherty K.
RT Positive and Negative Regulation of the Human Insulin Gene by Multiple Trans-acting Factors
RL J. Biol. Chem. 265:8285-8296 (1990).
RN [2]; RE0002878.
RX PUBMED: 1915886.
RA Scott V., Clark A. R., Hutton J. C., Docherty K.
RT Two proteins act as the IUF1 insulin gene enhancer binding factor
RL FEBS Lett. 290:27-30 (1991).
RN [3]; RE0002995.
RX PUBMED: 1406648.
RA Shelton K. D., Franklin A. J., Khoor A., Beechem J., Magnuson M. A.
RT Multiple elements in the upstream glucokinase promoter contrbute to transcription in insulinoma cells
RL Mol. Cell. Biol. 12:4578-4589 (1992).
RN [4]; RE0011841.
RX PUBMED: 8524276.
RA Peers B., Sharma S., Johnson T., Kamps M., Montminy M.
RT The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostain promoter: importance of the FPWMK motif and of the homeodomain
RL Mol. Cell. Biol. 15:7091-7097 (1995).
RN [5]; RE0015827.
RX PUBMED: 9252422.
RA Macfarlane W. M., Smith S. B., James R. F., Clifton A. D., Doza Y. N., Cohen P., Docherty K.
RT The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells
RL J. Biol. Chem. 272:20936-20944 (1997).
RN [6]; RE0015831.
RX PUBMED: 2690822.
RA Boam D. S., Docherty K.
RT A tissue-specific nuclear factor binds to multiple sites in the human insulin-gene enhancer
RL Biochem. J. 264:233-239 (1989).
RN [7]; RE0015832.
RX PUBMED: 10545531.
RA Hani E. H., Stoffers D. A., Chevre J. C., Durand E., Stanojevic V., Dina C., Habener J. F., Froguel P.
RT Defective mutations in the insulin promoter factor-1 (IPF-1) gene inlate-onset type 2 diabetes mellitus
RL J. Clin. Invest. 104:R41-R48 (1999).
RN [8]; RE0015833.
RX PUBMED: 10545530.
RA Macfarlane W. M., Frayling T. M., Ellard S., Evans J. C., Allen L. I., Bulman M. P., Ayres S., Shepherd M., Clark P., Millward A., Demaine A., Wilkin T., Docherty K., Hattersley A. T.
RT Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes
RL J. Clin. Invest. 104:R33-R39 (1999).
RN [9]; RE0015839.
RX PUBMED: 7590740.
RA Stoffel M., Stein R., Wright C. V., Espinosa R., Le Beau M. M., Bell G. I.
RT Localization of human homeodomain transcription factor insulin promoter factor 1 (IPF1) to chromosome band 13q12.1
RL Genomics 28:125-126 (1995).
RN [10]; RE0016132.
RX PUBMED: 8988180.
RA Stoffers D. A., Zinkin N. T., Stanojevic V., Clarke W. L., Habener J. F.
RT Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence.
RL Nat. Genet. 15:106-110 (1997).
RN [11]; RE0016240.
RX PUBMED: 8635654.
RA Inoue H., Riggs A. C., Tanizawa Y., Ueda K., Kuwano A., Liu L., Donis-Keller H., Permutt M. A.
RT Isolation, characterization, and chromosomal mapping of the human insulin promoter factor 1 (IPF-1) gene.
RL Diabetes 45:789-794 (1996).
RN [12]; RE0020529.
RX PUBMED: 10585868.
RA Wu H., Macfarlane W. M., Tadayyon M., Arch J. R., James R. F., Docherty K.
RT Insulin stimulates pancreatic-duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic beta cells
RL Biochem. J. 344:813-818 (1999).
RN [13]; RE0047549.
RX PUBMED: 11590182.
RA Gerrish K., Cissell M. A., Stein R.
RT The role of hepatic nuclear factor 1 alpha and PDX-1 in transcriptional regulation of the pdx-1 gene.
RL J. Biol. Chem. 276:47775-47784 (2001).
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