AC T04367
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ID T04367
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DT 02.03.2001 (created); rio.
DT 12.08.2008 (updated); tgo.
CO Copyright (C), QIAGEN.
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FA NCX
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SY enteric neuron homeobox; Enx; HOX11 like 1; HOX11L1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002303 TLX2; HGNC: Tlx2.
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CL C0006; homeo; 3.1.2.21.2.
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CP (cell lines:) NBTM, SH-SY5Y, SMS-KCN, SK.N-AS, GANB [1].
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FF mutations may cause neuronal intestinal dysplasia (NID) [3];
FF expression is upregulated after retinoic acid stimulation probably due to a potential retinoic acid response element (RARE) in the promoter [1];
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MX M00484 V$NCX_01.
MX M01420 V$NCX_02.
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DR TRANSPATH: MO000028224.
DR UniProtKB: O43763;
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RN [1]; RE0015841.
RX PUBMED: 10446220.
RA Iitsuka Y., Shimizu H., Kang M. M., Sasagawa K., Sekiya S., Tokuhisa T., Hatano M.
RT An enhancer element for expression of the Ncx (Enx, Hox11L1) gene in neural crest-derived cells
RL J. Biol. Chem. 274:24401-24407 (1999).
RN [2]; RE0015847.
RX PUBMED: 10343123.
RA Puliti A., Cinti R., Betsos N., Romeo G., Ceccherini I.
RT HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1-->p12 and mouse chromosome 6C3-D1
RL Cytogenet. Cell Genet. 84:115-117 (1999).
RN [3]; RE0015860.
RX PUBMED: 9176491.
RA Shirasawa S., Yunker A. M., Roth K. A., Brown G. A., Horning S., Korsmeyer S. J.
RT Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia and megacolon
RL Nat. Med. 3:646-650 (1997).
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