AC T04417
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ID T04417
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DT 11.04.2001 (created); rio.
DT 15.07.2008 (updated); tgo.
CO Copyright (C), QIAGEN.
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FA T-box protein 6
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SY T-box protein 6.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002432 Tbx6.
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CL C0044; T-box; 6.5.5.0.1.
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SF not closely related to any other T-box factor [1];
SF partially overlapping expression pattern with Brachyury [1];
SF T-box protein 6 -/- embryos lack trunk somites, have enlarged tail buds, kinked neural tubes, three neural tubes in the posterior paraxial tissue, vascular anomalies and die after day 12.5-13.5 because of hemorrhaging blood vessels and lack of heart beat [2];
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CP (E7.0:) early primitive streak, (E7.5:) primitive streak, paraxial mesoderm surrounding the streak, base of allantois, (E8.5-9.5:) unsegmented, presomitic mesoderm of tail region, caudal end of neural plate, (E12.5:) tail bud [1].
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FF essential for specification of posterior paraxial mesoderm [1] [2];
FF important role for the choose between mesodermal and neuronal differentiation pathway during gastrulation [2];
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MX M05345 V$TBX6_02.
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DR TRANSPATH: MO000028271.
DR UniProtKB: P70327;
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RN [1]; RE0016018.
RX PUBMED: 8954725.
RA Chapman D. L., Agulnik I., Hancock S., Silver L. M., Papaioannou V. E.
RT Tbx6, a mouse T-Box gene implicated in paraxial mesoderm formation at gastrulation
RL Dev. Biol. 180:534-542 (1996).
RN [2]; RE0016019.
RX PUBMED: 9490412.
RA Chapman D. L., Papaioannou V. E.
RT Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6
RL Nature 391:695-697 (1998).
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