AC T04610
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ID T04610
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DT 18.07.2001 (created); mas.
DT 10.07.2014 (updated); pro.
CO Copyright (C), QIAGEN.
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FA SXR
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SY NR1I2; PXR; steroid and xenobiotic receptor.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002750 NR1I2; HGNC: NR1I2.
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CL C0002; CC (rec).
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SZ 434 AA; 49.9 kDa (cDNA) (calc.).
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SQ LEVRPKESWNHADFVHVEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEG
SQ CKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEE
SQ RRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSS
SQ GCELPEPLQAPSREEAAKWSQVRKDLCSLKVSLQAAGGGWQCLELQTPSRQWRKEIFSLL
SQ PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWE
SQ CGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHR
SQ VVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF
SQ ATPLMQELFGITGS
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SC sequence taken from reference [1]: Blumberg et al., Genes Dev. 12, pp. 3195-3205 (1998)
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FT 2 352 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 38 110 
SM00399; c4gold.
FT 38 114 
PS51030; NUCLEAR_REC_DBD_2.
FT 39 115 
PF00105; Zinc finger, C4 type (two domains).
FT 41 107 
DNA-binding domain [1].
FT 141 434 
ligand-binding domain [1].
FT 245 404 
SM00430; holi.
FT 248 428 
PF00104; Ligand-binding domain of nuclear hormon.
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SF sequence very similar to human PXR T04617 (EMBL #AF061056) except of exchanges at pos. 1 (L instead of M) and pos. 215-233 (AAGGGWQCLELQTPSRQWR instead of LRGEDGSVWNYKPPADSGG) [1];
SF N-terminal amino acid is Leucine that has strikingly shown to function as translational initiator [1];
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CP (adult:) high levels in liver, moderate levels in small intestine [1].
EX adrenal cortex,,,adult; none; Northern blot; RNA (undefined); [1].
EX adrenal medulla,,,adult; none; Northern blot; RNA (undefined); [1].
EX brain,,,adult; none; Northern blot; RNA (undefined); [1].
EX heart,,,adult; none; Northern blot; RNA (undefined); [1].
EX kidney (right and left),,,adult; none; Northern blot; RNA (undefined); [1].
EX liver,,,adult; high; Northern blot; RNA (undefined); [1].
EX lung (right and left),,,adult; none; Northern blot; RNA (undefined); [1].
EX muscles,,,adult; none; Northern blot; RNA (undefined); [1].
EX pancreas,,,adult; none; Northern blot; RNA (undefined); [1].
EX placenta,,,adult; none; Northern blot; RNA (undefined); [1].
EX small intestine,,,adult; medium; Northern blot; RNA (undefined); [1].
EX stomach,,,adult; none; Northern blot; RNA (undefined); [1].
EX testis (right and left),,,adult; none; Northern blot; RNA (undefined); [1].
EX thymus,,,adult; none; Northern blot; RNA (undefined); [1].
EX thyroid gland,,,adult; none; Northern blot; RNA (undefined); [1].
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FF ligands: binds many steroid like corticosterone (very potent ligand), pregnenolone, dihydrotestosterone, estradiol, cortisone, cortisol (synergistic activation) [1];
FF also activated by products of steroid catabolism (5alpha-tetrahydroxycorticosterone, 5beta-tetrahydroxycorticosterone) [1];
FF involved in detoxification of cholestatic bile acids in response to lithocholic acid (LCA) probably through transcriptional induction of CYP3A enzymes [2];
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MX M00966 V$DR3_Q4.
MX M00965 V$DR4_Q2.
MX M07280 V$NR1NR2_Q3.
MX M00964 V$PXR_Q2.
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BS R10082.
BS R10083.
BS R10084.
BS R10085.
BS R62795.
BS R09957.
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DR TRANSPATH: MO000028443.
DR UniProtKB: O75469;
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RN [1]; RE0016451.
RX PUBMED: 9784494.
RA Blumberg B., Sabbagh W J. r., Juguilon H., Bolado J J. r., van Meter C. M., Ong E. S., Evans R. M.
RT SXR, a novel steroid and xenobiotic-sensing nuclear receptor
RL Genes Dev. 12:3195-3205 (1998).
RN [2]; RE0016456.
RX PUBMED: 11248086.
RA Xie W., Radominska-Pandya A., Shi Y., Simon C. M., Nelson M. C., Ong E. S., Waxman D. J., Evans R. M.
RT An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.
RL Proc. Natl. Acad. Sci. USA 98:3375-3380 (2001).
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//