AC T04630
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ID T04630
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DT 23.07.2001 (created); mas.
CO Copyright (C), QIAGEN.
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FA PXR
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SY NR1I2.
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OS rabbit, Oryctolagus cuniculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; lagomorpha; leporidae
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GE G002754 PXR.
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CL C0002; CC (rec).
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SZ 411 AA; 47.3 kDa (cDNA) (calc.).
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SQ MGGKPTISADEEEGPQTCRVCGDKANGYHFNVLTCEGCKGFFRRTVKRNARLRCPFRKGA
SQ CEITRKTRRQCQACRLRKCLESGMKKEMIMSDVAVAQRRALIKRKKRERMEAQPPGMQGL
SQ TGEQRMIIEELMDAQMKTFDTTFSHFKNFRLPEVLGSGCEIPESLQALTEEEAGRWRQIQ
SQ EELGTMKLSLQLRGEDGSVWNYTPPADRSGKKLFSLLPHLADMSTYMFKGIINFAKVISY
SQ FRDLPIEDQISLLKGATLELCLLRFNTVFNAETGTWECGRLSYCVEDPEGGFQQLLVDPL
SQ LKFHYMLKKLQLHKEEYVLMQAISLFSPDRPGVVQREVVDQLQERFAITLKAYIECSRPQ
SQ PTHRFLFLKIMAVLTELRTINAQHTQRLLRIQDTHPFATPLMRELFSTTDD
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SC translated from EMBL #AF188476
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FT 4 263 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 15 87 
SM00399; c4gold.
FT 15 91 
PS51030; NUCLEAR_REC_DBD_2.
FT 16 92 
PF00105; Zinc finger, C4 type (two domains).
FT 17 84 
DNA-binding domain [1].
FT 118 138 
helical region H1 [1].
FT 143 148 
helical region H2 [1].
FT 216 237 
helical region H3 [1].
FT 222 381 
SM00430; holi.
FT 225 405 
PF00104; Ligand-binding domain of nuclear hormon.
FT 246 255 helical region H4 [1].
FT 257 267 helical region H5 [1].
FT 285 289 helical region H6 [1].
FT 298 310 helical region H7 [1].
FT 314 325 helical region H8 [1].
FT 337 357 helical region H9 [1].
FT 366 392 helical region H10 [1].
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CP (adult:) high levels in liver [1], weaker levels in kidney and small intestine [1] [1].
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FF unprecedented broad range of ligands among nuclear receptor superfamily [1];
FF activating ligands: 17-hydroxyprogesterone (very potent), dexamethasone, rifampicin, clotrimazole, pregnenolone 16 alpha-carbonitrile, bisphosphonate ester SR12813 [1];
FF ligand spectrum different from orthologs of related species: for example not activated in the presence of 17alpha-hydroxypregnenolone in contrast to mouse ortholog T04618 [1];
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DR TRANSPATH: MO000028463.
DR EMBL: AF182217;
DR EMBL: AF188476;
DR UniProtKB: Q9TU02;
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RN [1]; RE0016488.
RX PUBMED: 10628745.
RA Jones S. A., Moore L. B., Shenk J. L., Wisely G. B., Hamilton G. A., McKee D. D., Tomkinson N. C., LeCluyse E. L., Lambert M. H., Willson T. M., Kliewer S. A., Moore J. T.
RT The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution
RL Mol. Endocrinol. 14:27-39 (2000).
RN [2]; RE0016510.
RX PUBMED: 10415106.
RA Zhang H., LeCulyse E., Liu L., Hu M., Matoney L., Zhu W., Yan B.
RT Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation
RL Arch. Biochem. Biophys. 368:14-22 (1999).
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