AC T04816
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ID T04816
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DT 10.10.2001 (created); mas.
DT 09.06.2015 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA FOXP2
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SY forkhead-related transcription factor 2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002816 FOXP2; HGNC: FOXP2.
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CL C0023; fork head; 3.3.1.16.2.
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FF plays a significant role in the ontogenetic and phylogenetic development of language [2];
FF transcription factor expressed in the brain, lungs, heart and gut;
FF in the brain, it is widely expressed in sensory, limbic and motor structures [3];
FF regulates the proliferation and/or migration of certain neuronal populations in the basal ganglia, cortex, cerebellum and thalamus [2];
FF mutated (disrupted) in a patient with severe speech and language disorder [1];
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MX M07403 V$FOXP2_01.
MX M08916 V$FOXP2_02.
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BS R40835.
BS R40837.
BS R40831.
BS R40833.
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DR TRANSPATH: MO000028623.
DR UniProtKB: O15409; FXP2_HUMAN.
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RN [1]; RE0016951.
RX PUBMED: 11586359.
RA Lai C. S., Fisher S. E., Hurst J. A., Vargha-Khadem F., Monaco A. P.
RT A forkhead-domain gene is mutated in a severe speech and language disorder
RL Nature 413:519-523 (2001).
RN [2]; RE0048523.
RX PUBMED: 15999329.
RA Benitez-Burraco A.
RT FOXP2: from the specific disorder to the molecular biology of language. II. Implications for the ontogenesis and phylogenesis of language
RL Rev. Neurol. 41:37-44 (2005).
RN [3]; RE0048525.
RX PUBMED: 15685218.
RA Vargha-Khadem F., Gadian D. G., Copp A., Mishkin M.
RT FOXP2 and the neuroanatomy of speech and language.
RL Nat. Rev. Neurosci. 6:131-138 (2005).
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