TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T04929 XX ID T04929 XX DT 26.11.2001 (created); rge. DT 05.02.2015 (updated); pro. CO Copyright (C), QIAGEN. XX FA IRF-4 XX SY interferon regulatory factor 4; IRF4; LSIRF; lymphocyte specific interferon regulatory factor; MUM1; NF-EM5. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G003134 IRF4; HGNC: IRF4. XX CL C0022; trp; XX SF IAD domain, conserved within IRF family, is responsible for the interactions and synergy with Ets family member PU.1 and with bHLH factor E47 [4] [2]; XX CP lymphocytes, myeloid cells. XX FF activator; FF activator of cytokine gene expression in both Th1 and Th2 cells [3]; FF cooperates with NF-ATc upon IL-4 gene induction in Th2 [3]; FF activate transcription synergistically with PU.1 in myeloid cells [4]; XX MX M04818 V$IRF4_07. MX M04855 V$IRF4_08. MX M07323 V$IRF4_Q5. MX M08886 V$IRF4_Q5_01. MX M01883 V$IRF4_Q6. MX M08887 V$IRF_Q4. MX M00772 V$IRF_Q6. MX M00972 V$IRF_Q6_01. XX BS R30511. BS R25477. BS R38781. BS R40385. BS R64952. BS R13560. BS R63314. BS R63327. BS R25968. BS R08170. BS R13438. BS R25473. BS R00945. BS R38516. BS R63326. XX DR TRANSPATH: MO000028705. DR TRANSCOMPEL: C00385. DR TRANSCOMPEL: C00387. DR UniProtKB: Q15306; XX RN [1]; RE0017258. RX PUBMED: 8921401. RA Grossman A., Mittrucker H. W., Nicholl J., Suzuki A., Chung S., Antonio L., Suggs S., Sutherland G. R., Siderovski D. P., Mak T. W. RT Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25 RL Genomics 37:229-233 (1996). RN [2]; RE0017830. RX PUBMED: 10586038. RA Meraro D., Hashmueli S., Koren B., Azriel A., Oumard A., Kirchhoff S., Hauser H., Nagulapalli S., Atchison M. L., Levi B.- Z. RT Protein-protein and DNA-protein interactions affect the activity of lymphoid-specific IFN regulatory factors. RL J. Immunol. 163:6468-6478 (1999). RN [3]; RE0022878. RX PUBMED: 12374808. RA Hu C. M., Jang S. Y., Fanzo J. C., Pernis A. B. RT Modulation of T cell cytokine production by interferon regulatory factor-4. RL J. Biol. Chem. 277:49238-49246 (2002). RN [4]; RE0023151. RX PUBMED: 12055236. RA Meraro D., Gleit-Kielmanowicz M., Hauser H., Levi B. Z. RT IFN-stimulated gene 15 is synergistically activated through interactions between the myelocyte/lymphocyte-specific transcription factors, PU.1, IFN regulatory factor-8/IFN consensus sequence binding protein, and IFN regulatory factor-4: characterization of a new subtype of IFN-stimulated response element. RL J. Immunol. 168:6224-6231 (2002). XX //