AC T04929
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ID T04929
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DT 26.11.2001 (created); rge.
DT 05.02.2015 (updated); pro.
CO Copyright (C), QIAGEN.
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FA IRF-4
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SY interferon regulatory factor 4; IRF4; LSIRF; lymphocyte specific interferon regulatory factor; MUM1; NF-EM5.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003134 IRF4; HGNC: IRF4.
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CL C0022; trp; 3.5.3.0.4.
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SF IAD domain, conserved within IRF family, is responsible for the interactions and synergy with Ets family member PU.1 and with bHLH factor E47 [4] [2];
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CP lymphocytes, myeloid cells.
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FF activator;
FF activator of cytokine gene expression in both Th1 and Th2 cells [3];
FF cooperates with NF-ATc upon IL-4 gene induction in Th2 [3];
FF activate transcription synergistically with PU.1 in myeloid cells [4];
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MX M04818 V$IRF4_07.
MX M04855 V$IRF4_08.
MX M07323 V$IRF4_Q5.
MX M08886 V$IRF4_Q5_01.
MX M01883 V$IRF4_Q6.
MX M08887 V$IRF_Q4.
MX M00772 V$IRF_Q6.
MX M00972 V$IRF_Q6_01.
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BS R30511.
BS R25477.
BS R38781.
BS R40385.
BS R64952.
BS R13560.
BS R63314.
BS R63327.
BS R25968.
BS R08170.
BS R13438.
BS R25473.
BS R00945.
BS R38516.
BS R63326.
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DR TRANSPATH: MO000028705.
DR TRANSCOMPEL: C00385.
DR TRANSCOMPEL: C00387.
DR UniProtKB: Q15306;
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RN [1]; RE0017258.
RX PUBMED: 8921401.
RA Grossman A., Mittrucker H. W., Nicholl J., Suzuki A., Chung S., Antonio L., Suggs S., Sutherland G. R., Siderovski D. P., Mak T. W.
RT Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25
RL Genomics 37:229-233 (1996).
RN [2]; RE0017830.
RX PUBMED: 10586038.
RA Meraro D., Hashmueli S., Koren B., Azriel A., Oumard A., Kirchhoff S., Hauser H., Nagulapalli S., Atchison M. L., Levi B.- Z.
RT Protein-protein and DNA-protein interactions affect the activity of lymphoid-specific IFN regulatory factors.
RL J. Immunol. 163:6468-6478 (1999).
RN [3]; RE0022878.
RX PUBMED: 12374808.
RA Hu C. M., Jang S. Y., Fanzo J. C., Pernis A. B.
RT Modulation of T cell cytokine production by interferon regulatory factor-4.
RL J. Biol. Chem. 277:49238-49246 (2002).
RN [4]; RE0023151.
RX PUBMED: 12055236.
RA Meraro D., Gleit-Kielmanowicz M., Hauser H., Levi B. Z.
RT IFN-stimulated gene 15 is synergistically activated through interactions between the myelocyte/lymphocyte-specific transcription factors, PU.1, IFN regulatory factor-8/IFN consensus sequence binding protein, and IFN regulatory factor-4: characterization of a new subtype of IFN-stimulated response element.
RL J. Immunol. 168:6224-6231 (2002).
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