TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T04940 XX ID T04940 XX DT 27.11.2001 (created); rge. DT 15.01.2016 (updated); mkl. CO Copyright (C), QIAGEN. XX FA NFAT5 XX SY NFAT5; tone-binding protein; tonebp; tonicity-responsive enhancer-binding protein. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G005535 NFAT5; HGNC: NFAT5. XX HO the only NF-AT-like protein in Drosophila. XX CL C0052; REL/NFAT; XX SF the most distant member of the NF-AT family: has no calcineurin binding domain, forms a stable dimer in solution, dimerization is obligatory for DNA binding and transcriptional activity [3]; SF DBD/RHD contains two parts, N-terminal DNA binding loop and C-terminal dimerization surface [3]; SF C-terminus of NFAT5 possesses transactivation capacity [3]; SF positions of domains are different from those given in [3]; XX CP immune cells: T-cells, B-cells [3]. XX FF activator [3]; FF the only NF-AT family member regulated by osmotic stress (elevated sodium concentration, hypertonic stimulation) [3]; FF activates plasmids through osmotic response elements, OREs [3]; FF activates cytokine genes in osmotically stressed T-cells [3]; XX MX M03556 V$NFAT5_Q5_01. MX M03881 V$NFAT5_Q5_02. MX M07328 V$NFAT5_Q5_03. MX M07608 V$NFAT_Q3. XX BS R31829. BS R41541. BS R41543. BS R41545. BS R38652. BS R38653. BS R38654. BS R21231. BS R40679. BS R40680. XX DR TRANSPATH: MO000028715. DR UniProtKB: O94916; XX RN [1]; RE0017300. RX PUBMED: 10377394. RA Lopez-Rodriguez C., Aramburu J., Rakeman A. S., Rao A. RT NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun RL Proc. Natl. Acad. Sci. USA 96:7214-7219 (1999). RN [2]; RE0017301. RX PUBMED: 10051678. RA Miyakawa H., Woo S. K., Dahl S. C., Handler J. S., Kwon H. M. RT Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity RL Proc. Natl. Acad. Sci. USA 96:2538-2542 (1999). RN [3]; RE0022955. RX PUBMED: 11485737. RA Lopez-Rodriguez C., Aramburu J., Jin L., Rakeman A. S., Michino M., Rao A. RT Bridging the NFAT and NF-kappaB families: NFAT5 dimerization regulates cytokine gene transcription in response to osmotic stress. RL Immunity 15:47-58 (2001). RN [4]; RE0070942. RX PUBMED: 21209322. RA Gallazzini M., Heussler G. E., Kunin M., Izumi Y., Burg M. B., Ferraris J. D. RT High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization. RL Mol. Biol. Cell 22:703-714 (2011). XX //