AC T04940
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ID T04940
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DT 27.11.2001 (created); rge.
DT 15.01.2016 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA NFAT5
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SY NFAT5; tone-binding protein; tonebp; tonicity-responsive enhancer-binding protein.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G005535 NFAT5; HGNC: NFAT5.
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HO the only NF-AT-like protein in Drosophila.
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CL C0052; REL/NFAT; 6.1.3.0.5.
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SF the most distant member of the NF-AT family: has no calcineurin binding domain, forms a stable dimer in solution, dimerization is obligatory for DNA binding and transcriptional activity [3];
SF DBD/RHD contains two parts, N-terminal DNA binding loop and C-terminal dimerization surface [3];
SF C-terminus of NFAT5 possesses transactivation capacity [3];
SF positions of domains are different from those given in [3];
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CP immune cells: T-cells, B-cells [3].
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FF activator [3];
FF the only NF-AT family member regulated by osmotic stress (elevated sodium concentration, hypertonic stimulation) [3];
FF activates plasmids through osmotic response elements, OREs [3];
FF activates cytokine genes in osmotically stressed T-cells [3];
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MX M03556 V$NFAT5_Q5_01.
MX M03881 V$NFAT5_Q5_02.
MX M07328 V$NFAT5_Q5_03.
MX M07608 V$NFAT_Q3.
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BS R31829.
BS R41541.
BS R41543.
BS R41545.
BS R38652.
BS R38653.
BS R38654.
BS R21231.
BS R40679.
BS R40680.
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DR TRANSPATH: MO000028715.
DR UniProtKB: O94916;
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RN [1]; RE0017300.
RX PUBMED: 10377394.
RA Lopez-Rodriguez C., Aramburu J., Rakeman A. S., Rao A.
RT NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun
RL Proc. Natl. Acad. Sci. USA 96:7214-7219 (1999).
RN [2]; RE0017301.
RX PUBMED: 10051678.
RA Miyakawa H., Woo S. K., Dahl S. C., Handler J. S., Kwon H. M.
RT Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity
RL Proc. Natl. Acad. Sci. USA 96:2538-2542 (1999).
RN [3]; RE0022955.
RX PUBMED: 11485737.
RA Lopez-Rodriguez C., Aramburu J., Jin L., Rakeman A. S., Michino M., Rao A.
RT Bridging the NFAT and NF-kappaB families: NFAT5 dimerization regulates cytokine gene transcription in response to osmotic stress.
RL Immunity 15:47-58 (2001).
RN [4]; RE0070942.
RX PUBMED: 21209322.
RA Gallazzini M., Heussler G. E., Kunin M., Izumi Y., Burg M. B., Ferraris J. D.
RT High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization.
RL Mol. Biol. Cell 22:703-714 (2011).
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