AC T05015
XX
ID T05015
XX
DT 21.01.2002 (created); mas.
DT 03.07.2015 (updated); jmh.
CO Copyright (C), QIAGEN.
XX
FA c-Ets-1
XX
SY c-Ets-1 p54; Ets-1; Ets1; p54.
XX
OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G002967 Ets1.
XX
CL C0016; ETS; 3.5.2.1.1.
XX
CP (adult:) expressed in liver (hepatocytes, Kupffer cells, sinusoidal endothelial cells, liver myofibroblasts, hepatic stellate cells) [3]; identified in GH4 pituitary cells [1] [3] [1].
XX
FF activator [1];
FF a critical component of the Ras signaling pathway in pituitary cells [1];
FF expression down-regulated during in vitro activation of hepatic stellate cells (HSC): high expression in HSCs up to 2 days after plating (resting cells), but low expression in HSCs after 7 days of plating (activated cells) [3];
XX
IN T09945 p300; rat, Rattus norvegicus.
XX
MX M00032 V$CETS1P54_01.
MX M00074 V$CETS1P54_02.
MX M01078 V$CETS1P54_03.
MX M01870 V$CETS1_Q6.
MX M00339 V$ETS1_B.
MX M08881 V$ETSLIKE_Q4.
MX M00340 V$ETS_B.
MX M00771 V$ETS_Q4.
MX M00971 V$ETS_Q6.
XX
BS R19160.
BS R32610.
BS R34248.
BS R23151.
BS R25994.
BS R26320.
BS R35032.
BS R68628.
BS R68629.
BS R39545.
BS R39546.
BS R26519.
BS R26510.
BS R31098.
BS R01269.
BS R20631.
BS R32677.
BS R32609.
XX
DR TRANSPATH: MO000028773.
DR TRANSCOMPEL: C00131.
DR TRANSCOMPEL: C00616.
DR UniProtKB: P41156;
XX
RN [1]; RE0016686.
RX PUBMED: 8798730.
RA Bradford A. P., Conrad K. E., Tran P. H., Ostrowski M. C., Gutierrez-Hartmann A.
RT GHF-1/Pit-1 functions as a cell-specific integrator of Ras signaling by targeting the Ras pathway to a composite Ets-1/GHF-1 response element.
RL J. Biol. Chem. 271:24639-24648 (1996).
RN [2]; RE0017453.
RX PUBMED: 8139017.
RA Bellacosa A., Datta K., Bear S. E., Patriotis C., Lazo P. A., Copeland N. G., Jenkins N. A., Tsichlis P. N.
RT Effects of provirus integration in the Tpl-1/Ets-1 locus in Moloney murine leukemia virus-induced rat T-cell lymphomas: levels of expression, polyadenylation, transcriptional initiation, and differential splicing of the Ets-1 mRNA
RL J. Virol. 68:2320-2330 (1994).
RN [3]; RE0017454.
RX PUBMED: 10595913.
RA Knittel T., Kobold D., Dudas J., Saile B., Ramadori G.
RT Role of the Ets-1 transcription factor during activation of rat hepatic stellate cells in culture
RL Am. J. Pathol. 155:1841-1848 (1999).
XX
//