AC T05051
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ID T05051
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DT 28.02.2002 (created); mas.
DT 12.04.2010 (updated); pch.
CO Copyright (C), QIAGEN.
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FA BTEB3
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SY basic transcription element binding protein 3; bte-binding protein 3; BTEB-3; FKLF-2; FKLF2; KLF13; Krueppel-like factor 13; novel SP1-like zinc finger transcription factor 1; NSLP1; Rantes factor of late activated T lymphocytes-1; RFLAT-1; transcription factor BTEB3; transcription factor NSLP1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006339 KLF13; HGNC: KLF13.
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CL C0001; CH; 2.3.1.2.13.
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SF probably phosphorylated [1];
SF contains 3 domains which are responsible for transcriptional repression (repression domains 1,2,3) and which can function independently of each other, but combination of all 3 domains is necessary for full repression activity [3];
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CP (adult:) high levels in heart, skeletal muscle, bone marrow [4] and thymus, peripheral blood lymphocytes [1]; (cell lines:) expressed in various hematopoietic cell lines [1]; expression in erythroid, myeloid and lymphoid cell line [4] [4] [1].
EX adrenal gland (right and left),,,adult; none; Northern blot; mRNA (poly-A); [4].
EX blood,basophil granulocyte,Circulatory System & Hematopoietic System,adult; very high; Northern blot; mRNA (poly-A); [1].
EX blood,eosinophil granulocyte,Circulatory System & Hematopoietic System,adult; very high; Northern blot; mRNA (poly-A); [1].
EX blood,lymphocyte,Circulatory System & Hematopoietic System,adult; very high; Northern blot; mRNA (poly-A); [1].
EX blood,monocyte,Circulatory System & Hematopoietic System,adult; very high; Northern blot; mRNA (poly-A); [1].
EX blood,neutrophil granulocyte,Circulatory System & Hematopoietic System,adult; very high; Northern blot; mRNA (poly-A); [1].
EX bone marrow,,,adult; detectable; Northern blot; mRNA (poly-A); [4].
EX brain,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX brain,,,adult; none; Northern blot; mRNA (poly-A); [4].
EX heart,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX heart,,,adult; detectable; Northern blot; mRNA (poly-A); [4].
EX kidney (right and left),,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX kidney (right and left),,,adult; none; Northern blot; mRNA (poly-A); [4].
EX liver,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX liver,,,adult; none; Northern blot; mRNA (poly-A); [4].
EX lung (right and left),,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX lung (right and left),,,adult; none; Northern blot; mRNA (poly-A); [4].
EX lymph node,,,adult; none; Northern blot; mRNA (poly-A); [4].
EX mucosa of colon,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX muscles,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX muscles,,,adult; detectable; Northern blot; mRNA (poly-A); [4].
EX ovary (right and left),,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX pancreas,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX pancreas,,,adult; none; Northern blot; mRNA (poly-A); [4].
EX placenta,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX placenta,,,adult; none; Northern blot; mRNA (poly-A); [4].
EX prostate gland,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX small intestine,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX spinal cord,,,adult; none; Northern blot; mRNA (poly-A); [4].
EX spleen,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX stomach,,,adult; none; Northern blot; mRNA (poly-A); [4].
EX testis (right and left),,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX thymus,,,adult; very high; Northern blot; mRNA (poly-A); [1].
EX thyroid gland,,,adult; none; Northern blot; mRNA (poly-A); [4].
EX trachea,,,adult; detectable; Northern blot; mRNA (poly-A); [4].
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FF activator (e.g. of RANTES gene G001239) and repressor (e.g. of CYP1A1 gene G000734) [3] [1];
FF repression sensitive to trichostatin A (TSA), wherefore N-terminus is responsible: therefore N-terminus may interact with co-repressors that are important for the recruitment of histone deacetylases [3];
FF repressive effect on transcription seems not only be due to its N-terminal repression domains (and recruited co-repressors) but also may depend on competition with activator Sp1 on the same binding site [3];
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IN T05062 HDAC1; long-tailed hamster, Cricetulus longicaudatus.
IN T05063 sin3a; long-tailed hamster, Cricetulus longicaudatus.
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MX M01865 V$BTEB3_Q5.
MX M03912 V$KLF13_01.
MX M07461 V$KLF_Q3.
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BS R12279.
BS R25966.
BS R15620.
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DR TRANSPATH: MO000028794.
DR TRANSCOMPEL: C00335.
DR UniProtKB: Q9Y2Y9;
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RN [1]; RE0017566.
RX PUBMED: 10023774.
RA Song A., Chen Y. F., Thamatrakoln K., Storm T. A., Krensky A. M.
RT RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes.
RL Immunity 10:93-103 (1999).
RN [2]; RE0017584.
RX PUBMED: 10415854.
RA Cook T., Gebelein B., Urrutia R.
RT Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors
RL Ann. N. Y. Acad. Sci. 880:94-102 (1999).
RN [3]; RE0017585.
RX PUBMED: 11477107.
RA Kaczynski J., Zhang J. S., Ellenrieder V., Conley A., Duenes T., Kester H., van der Burg B., Urrutia R.
RT The Sp1-like protein BTEB3 inhibits transcription via the basic transcription element box by interacting with mSin3A and HDAC-1 co-repressors and competing with Sp1
RL J. Biol. Chem. 276:36749-36756 (2001).
RN [4]; RE0017587.
RX PUBMED: 10828046.
RA Asano H., Li X. S., Stamatoyannopoulos G.
RT FKLF-2: a novel Kruppel-like transcriptional factor that activates globin and other erythroid lineage genes
RL Blood 95:3578-3584 (2000).
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