AC T05069
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ID T05069
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DT 18.03.2002 (created); mas.
DT 23.11.2015 (updated); sup.
CO Copyright (C), QIAGEN.
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FA GMEB-1
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SY glucocorticoid modulatory element binding protein-1; GMEB1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004037 GMEB1; HGNC: GMEB1.
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CL C0077; SAND; 5.3.3.1.1.
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SF contains KDWK domain [2];
SF maybe discrepancy between calculated (61 kDa) and experimentally determined molecular mass which is higher at least for rat homolog T05072 (88 kDa) [1];
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EX brain,,,adult; detectable; Western blot; protein; [2].
EX heart,,,adult; detectable; Western blot; protein; [2].
EX kidney (right and left),,,adult; detectable; Western blot; protein; [2].
EX liver,,,adult; detectable; Western blot; protein; [2].
EX lung (right and left),,,adult; detectable; Western blot; protein; [2].
EX pancreas,,,adult; detectable; Western blot; protein; [2].
EX spleen,,,adult; detectable; Western blot; protein; [2].
EX stomach,,,adult; detectable; Western blot; protein; [2].
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FF interacts with HSP27 (heat shock protein 27) [2];
FF nuclear localization shown in transfected cells [2];
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DR TRANSPATH: MO000031260.
DR UniProtKB: Q9Y692;
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RN [1]; RE0011313.
RX PUBMED: 7665613.
RA Oshima H., Szapary D., Simons S. S.
RT The factor binding of the glucocorticoid modulatory element of the tyrosine aminotransferase gene is a novel and ubiquitous heteromeric complex
RL J. Biol. Chem. 270:21893-21901 (1995).
RN [2]; RE0017627.
RX PUBMED: 10386584.
RA Theriault J. R., Charette S. J., Lambert H., Landry J.
RT Cloning and characterization of hGMEB1, a novel glucocorticoid modulatory element binding protein
RL FEBS Lett. 452:170-176 (1999).
RN [3]; RE0049154.
RX PUBMED: 15555560.
RA Tsuruma K., Nakagawa T., Shirakura H., Hayashi N., Uehara T., Nomura Y.
RT Regulation of procaspase-2 by glucocorticoid modulatory element-binding protein 1 through the interaction with caspase recruitment domain.
RL Biochem. Biophys. Res. Commun. 325:1246-1251 (2004).
RN [4]; RE0049159.
RX PUBMED: 16497673.
RA Tsuruma K., Nakagawa T., Morimoto N., Minami M., Hara H., Uehara T., Nomura Y.
RT Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury.
RL J. Biol. Chem. 281:11397-11404 (2006).
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