AC T05100
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ID T05100
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DT 06.05.2002 (created); mas.
DT 16.07.2008 (updated); tgo.
CO Copyright (C), QIAGEN.
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FA gsh-1
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SY Gsh-1; gsh1; Homeobox Protein Gsh-1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004094 Gsx1.
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HO Antennapedia (Drosophila).
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CL C0006; homeo; 3.1.1.12.1.
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SF homeodomain shares high sequence similarity with Antennapedia family of homeodomain proteins, which is even higher than that of most proteins encoded by clustered homeobox genes [3];
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EX central nervous system,,,Theiler Stage 17; detectable; Northern blot; RNA (undefined); [2].
EX central nervous system,,,Theiler Stage 19; detectable; Northern blot; RNA (undefined); [2].
EX central nervous system,,,Theiler Stage 20; detectable; Northern blot; RNA (undefined); [2].
EX diencephalon,,,adult; detectable; Northern blot; total RNA; [3].
EX hypothalamus,,,adult; detectable; Northern blot; total RNA; [3].
EX mesencephalon,,,adult; detectable; Northern blot; total RNA; [3].
EX rhombencephalon,,,adult; detectable; Northern blot; total RNA; [3].
EX spinal cord,,,adult; detectable; Northern blot; total RNA; [3].
EX thalamus,,,adult; detectable; Northern blot; total RNA; [3].
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FF binds to consensus DNA-binding site G(CT/CA)CATTA(G/A) [2];
FF required for normal pituitary development because knock-out leads to smaller size and hypocellulism with reduced numbers of growth hormone- and prolactine-expressing cells [3];
FF shown to be essential for growth hormone-releasing hormone (GHRH) gene expression in the arcuate nucleus of the hypothalamus [3];
FF required for normal levels of several pituitary hormones like GH (growth hormone), PRL (prolactin), ACTH (adrenocorticotrophic hormone), LH (luteinizing hormone) because gene knock-out results in significant decrease of levels of these hormones [3];
FF seems to control expression of its own gene because binds to promoter region R12427 of its own gene [3];
FF knock-out leads to reduced viability of animals and dwarfism [3];
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MX M05339 V$GSH1_01.
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DR TRANSPATH: MO000031280.
DR UniProtKB: P31315;
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RN [1]; RE0003904.
RX PUBMED: 1683707.
RA Singh G., Kaur S., Stock J. L., Jenkins N. A., Gilbert D. J., Copeland N. G., Potter S. S.
RT Identification of 10 murine homeobox genes
RL Proc. Natl. Acad. Sci. USA 88:10706-10710 (1991).
RN [2]; RE0017736.
RX PUBMED: 8589431.
RA Valerius M. T., Li H., Stock J. L., Weinstein M., Kaur S., Singh G., Potter S. S.
RT Gsh-1: a novel murine homeobox gene expressed in the central nervous system
RL Dev. Dyn. 203:337-351 (1995).
RN [3]; RE0017737.
RX PUBMED: 8631293.
RA Li H., Zeitler P. S., Valerius M. T., Small K., Potter S. S.
RT Gsh-1, an orphan Hox gene, is required for normal pituitary development
RL EMBO J. 15:714-724 (1996).
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