AC T05167
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ID T05167
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DT 29.07.2002 (created); mas.
DT 18.08.2010 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA PUR1
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SY CAGER-1; PUR-alpha; pura; purine-rich single- stranded DNA-binding protein alpha; ssCRE-BP; transcriptional activator protein pur-alpha.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004539 Pura.
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CL C0064; unchar-DBD; 0.0.5.0.1.
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SF 71% amino acid identity between PUR1 T05167 and PUR-beta T05172 [3];
SF alpha-helical region seems to be important for interaction with retinoblastoma protein [2];
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FF assumed to bind to single-stranded DNA with a consensus found in gene flanking regions and DNA replication initiation zones [3];
FF seems to interact with retinoblastoma protein [1];
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IN T09420 neurofibromin1; human, Homo sapiens.
IN T09276 PUR-beta; mouse, Mus musculus.
IN T19301 TEF-1-xbb2; human, Homo sapiens.
IN T09277 YB-1; mouse, Mus musculus.
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MX M01721 V$PUR1_Q4.
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BS R12762.
BS R12760.
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DR TRANSPATH: MO000032997.
DR UniProtKB: P42669;
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RN [1]; RE0011395.
RX PUBMED: 7592647.
RA Johnson E. M., Chen P.-L., Krackmarov C. P., Barr S. M., Kanovsky M., Ma Z.-W., Lee W.-H.
RT Association of human Puralpha with the retinoblastoma protein, Rb, regulates binding to the single-stranded DNA Puralpha recognition element
RL J. Biol. Chem. 270:24352-24360 (1995).
RN [2]; RE0017923.
RX PUBMED: 7959008.
RA Ma Z. W., Bergemann A. D., Johnson E. M.
RT Conservation in human and mouse Pur alpha of a motif common to several proteins involved in initiation of DNA replication
RL Gene 149:311-314 (1994).
RN [3]; RE0017924.
RX PUBMED: 9334258.
RA Kelm RJ J. r., Elder P. K., Strauch A. R., Getz M. J.
RT Sequence of cDNAs encoding components of vascular actin single-stranded DNA-binding factor 2 establish identity to Puralpha and Purbeta
RL J. Biol. Chem. 272:26727-26733 (1997).
RN [4]; RE0017925.
RX PUBMED: 11751932.
RA Carlini L. E., Getz M. J., Strauch A. R., Kelm RJ J. r.
RT Cryptic MCAT enhancer regulation in fibroblasts and smooth muscle cells. Suppression of TEF-1 mediated activation by the single-stranded DNA-binding proteins, Pur alpha, Pur beta, and MSY1
RL J. Biol. Chem. 277:8682-8692 (2002).
RN [5]; RE0017928.
RX PUBMED: 7739527.
RA Sun S., Stoflet E. S., Cogan J. G., Strauch A. R., Getz M. J.
RT Negative regulation of the vascular smooth muscle alpha-actin gene in fibroblasts and myoblasts: disruption of enhancer function by sequence-specific single-stranded-DNA-binding proteins.
RL Mol. Cell. Biol. 15:2429-2436 (1995).
RN [6]; RE0064266.
RX PUBMED: 18218617.
RA Patrakitkomjorn S., Kobayashi D., Morikawa T., Wilson M. M., Tsubota N., Irie A., Ozawa T., Aoki M., Arimura N., Kaibuchi K., Saya H., Araki N.
RT Neurofibromatosis type 1 (NF1) tumor suppressor, neurofibromin, regulates the neuronal differentiation of PC12 cells via its associating protein, CRMP-2.
RL J. Biol. Chem. 283:9399-9413 (2008).
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