TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T05167 XX ID T05167 XX DT 29.07.2002 (created); mas. DT 18.08.2010 (updated); jtr. CO Copyright (C), QIAGEN. XX FA PUR1 XX SY CAGER-1; PUR-alpha; pura; purine-rich single- stranded DNA-binding protein alpha; ssCRE-BP; transcriptional activator protein pur-alpha. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G004539 Pura. XX CL C0064; unchar-DBD; XX SF 71% amino acid identity between PUR1 T05167 and PUR-beta T05172 [3]; SF alpha-helical region seems to be important for interaction with retinoblastoma protein [2]; XX FF assumed to bind to single-stranded DNA with a consensus found in gene flanking regions and DNA replication initiation zones [3]; FF seems to interact with retinoblastoma protein [1]; XX IN T09420 neurofibromin1; human, Homo sapiens. IN T09276 PUR-beta; mouse, Mus musculus. IN T19301 TEF-1-xbb2; human, Homo sapiens. IN T09277 YB-1; mouse, Mus musculus. XX MX M01721 V$PUR1_Q4. XX BS R12762. BS R12760. XX DR TRANSPATH: MO000032997. DR UniProtKB: P42669; XX RN [1]; RE0011395. RX PUBMED: 7592647. RA Johnson E. M., Chen P.-L., Krackmarov C. P., Barr S. M., Kanovsky M., Ma Z.-W., Lee W.-H. RT Association of human Puralpha with the retinoblastoma protein, Rb, regulates binding to the single-stranded DNA Puralpha recognition element RL J. Biol. Chem. 270:24352-24360 (1995). RN [2]; RE0017923. RX PUBMED: 7959008. RA Ma Z. W., Bergemann A. D., Johnson E. M. RT Conservation in human and mouse Pur alpha of a motif common to several proteins involved in initiation of DNA replication RL Gene 149:311-314 (1994). RN [3]; RE0017924. RX PUBMED: 9334258. RA Kelm RJ J. r., Elder P. K., Strauch A. R., Getz M. J. RT Sequence of cDNAs encoding components of vascular actin single-stranded DNA-binding factor 2 establish identity to Puralpha and Purbeta RL J. Biol. Chem. 272:26727-26733 (1997). RN [4]; RE0017925. RX PUBMED: 11751932. RA Carlini L. E., Getz M. J., Strauch A. R., Kelm RJ J. r. RT Cryptic MCAT enhancer regulation in fibroblasts and smooth muscle cells. Suppression of TEF-1 mediated activation by the single-stranded DNA-binding proteins, Pur alpha, Pur beta, and MSY1 RL J. Biol. Chem. 277:8682-8692 (2002). RN [5]; RE0017928. RX PUBMED: 7739527. RA Sun S., Stoflet E. S., Cogan J. G., Strauch A. R., Getz M. J. RT Negative regulation of the vascular smooth muscle alpha-actin gene in fibroblasts and myoblasts: disruption of enhancer function by sequence-specific single-stranded-DNA-binding proteins. RL Mol. Cell. Biol. 15:2429-2436 (1995). RN [6]; RE0064266. RX PUBMED: 18218617. RA Patrakitkomjorn S., Kobayashi D., Morikawa T., Wilson M. M., Tsubota N., Irie A., Ozawa T., Aoki M., Arimura N., Kaibuchi K., Saya H., Araki N. RT Neurofibromatosis type 1 (NF1) tumor suppressor, neurofibromin, regulates the neuronal differentiation of PC12 cells via its associating protein, CRMP-2. RL J. Biol. Chem. 283:9399-9413 (2008). XX //