AC T05403
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ID T05403
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DT 27.01.2003 (created); sth.
DT 23.06.2014 (updated); asv.
CO Copyright (C), QIAGEN.
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FA PDEF
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SY bA375E1.3; PDEF; prostate epithelium- specific Ets transcription factor; prostate epithelium-specific Ets transcription factor; prostate-derived Ets factor; PSE; RP11-375E1__A.3; SAM pointed domain containing ets transcription factor; SPDEF.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G005032 SPDEF; HGNC: SPDEF.
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CL C0016; ETS; 3.5.2.7.1.
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SF prefers binding to a GGAT rather than a GGAA core [1];
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CP restricted to luminal epithelial cells [1].
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FF androgen-independent transcriptional activator of the PSA promoter [1];
FF important regulator of prostate gland and/ or prostate cancer development [1];
FF interacts directly with the DNA binding domain of androgen receptor and enhances androgen-mediated activation of the PSA promoter [1];
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IN T11165 NKX3A; human, Homo sapiens.
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MX M02075 V$PDEF_02.
MX M03991 V$SPDEF_05.
MX M03992 V$SPDEF_06.
MX M03993 V$SPDEF_07.
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DR TRANSPATH: MO000054292.
DR UniProtKB: O95238; O95238.
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RN [1]; RE0022313.
RX PUBMED: 10625666.
RA Oettgen P., Finger E., Sun Z., Akbarali Y., Thamrongsak U., Boltax J., Grall F., Dube A., Weiss A., Brown L., Quinn G., Kas K., Endress G., Kunsch C., Libermann T. A.
RT PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression.
RL J. Biol. Chem. 275:1216-1225 (2000).
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